Atypical induction of HIF-1&#945; expression by pericellular Notch1 signaling suffices for the malignancy of glioblastoma multiforme cells.

Lee, Jungwhoi; Kim, Eunsoo; Chong, Kyuha; Ryu, Seung-Wook; Kim, Chungyeul; Choi, Kyungsun; Kim, Jae-Hoon; Choi, Chulhee

Atypical induction of HIF-1α expression by pericellular Notch1 signaling suffices for the malignancy of glioblastoma multiforme cells.

Lee, Jungwhoi; Kim, Eunsoo; Chong, Kyuha; Ryu, Seung-Wook; Kim, Chungyeul; Choi, Kyungsun; Kim, Jae-Hoon; Choi, Chulhee.

Afiliação

Lee J; Department of Applied Life Science, Sustainable Agriculture Research Institute (SARI), Jeju National University, 102 Jejudaehak-ro, Jeju, Jeju-do, 63243, Republic of Korea. sdjd1108@kaist.ac.kr.
Kim E; ILIAS Biologics Inc, 40-20, Techno 6-ro, Yuseong-gu, Daejeon, 34014, Republic of Korea.
Chong K; Department of Neurosurgery, Korea University Guro Hospital, Korea University Medicine, Korea University College of Medicine, 148 Gurodong-ro, Guro-gu, Seoul, 08308, Republic of Korea.
Ryu SW; Laboratory of Photo-Theranosis and Bioinformatics for Tumors, Department of Neurosurgery, Samsung Medical Center, 81 Irwon-Ro, Gangnam-gu, Seoul, 06351, Republic of Korea.
Kim C; Department of Neurosurgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-gu, Seoul, 06351, Republic of Korea.
Choi K; ILIAS Biologics Inc, 40-20, Techno 6-ro, Yuseong-gu, Daejeon, 34014, Republic of Korea.
Kim JH; Department of Pathology, Korea University Guro Hospital, Korea University Medicine, Korea University College of Medicine, 148 Gurodong-ro, Guro-gu, Seoul, 08308, Republic of Korea.
Choi C; ILIAS Biologics Inc, 40-20, Techno 6-ro, Yuseong-gu, Daejeon, 34014, Republic of Korea.

Cell Mol Life Sci ; 79(10): 537, 2022 Oct 02.

Article em En | MEDLINE | ID: mdl-36183290

Assuntos

Glioblastoma; Secretases da Proteína Precursora do Amiloide/metabolismo; Animais; Linhagem Celular Tumoral; Doxiciclina; Glioblastoma/patologia; Humanos; Subunidade alfa do Fator 1 Induzível por Hipóxia/genética; Subunidade alfa do Fator 1 Induzível por Hipóxia/metabolismo; Camundongos; RNA Interferente Pequeno/genética; Receptor Notch1/genética; Transdução de Sinais; Temozolomida; Microambiente Tumoral

Palavras-chave

Abnormal HIF-1α; Chemoresistance; GBM; Juxtacrine signaling; Notch1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glioblastoma Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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