Naltrexone Transport by a Proton-Coupled Organic Cation Antiporter in hCMEC/D3 Cells, an in Vitro Human Blood-Brain Barrier Model.

Kitamura, Atsushi; Higuchi, Kei; Kurosawa, Toshiki; Okura, Takashi; Kubo, Yoshiyuki; Deguchi, Yoshiharu

Kitamura, Atsushi; Higuchi, Kei; Kurosawa, Toshiki; Okura, Takashi; Kubo, Yoshiyuki; Deguchi, Yoshiharu.

Afiliação

Kitamura A; Laboratory of Drug Disposition & Pharmacokinetics, Faculty of Pharma-Science, Teikyo University.
Higuchi K; Laboratory of Drug Disposition & Pharmacokinetics, Faculty of Pharma-Science, Teikyo University.
Kurosawa T; Laboratory of Drug Disposition & Pharmacokinetics, Faculty of Pharma-Science, Teikyo University.
Okura T; Laboratory of Drug Disposition & Pharmacokinetics, Faculty of Pharma-Science, Teikyo University.
Kubo Y; Laboratory of Drug Disposition & Pharmacokinetics, Faculty of Pharma-Science, Teikyo University.
Deguchi Y; Laboratory of Drug Disposition & Pharmacokinetics, Faculty of Pharma-Science, Teikyo University.

Biol Pharm Bull ; 45(10): 1585-1589, 2022.

Article em En | MEDLINE | ID: mdl-36184519

Assuntos

Antiporters; Barreira Hematoencefálica; Cloreto de Amônio; Analgésicos Opioides/metabolismo; Antiporters/metabolismo; Transporte Biológico; Barreira Hematoencefálica/metabolismo; Cátions/metabolismo; Humanos; Naltrexona/metabolismo; Naltrexona/farmacologia; Antagonistas de Entorpecentes/farmacologia; Prótons; Azida Sódica/metabolismo

Palavras-chave

bloodbrain barrier; membrane transport; naltrexone; organic cation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Barreira Hematoencefálica / Antiporters Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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