Urinary T cells are detected in patients with immune checkpoint inhibitor-associated immune nephritis that are clonotypically identical to kidney T cell infiltrates.

Singh, Shailbala; Clemente, Leticia C; Parra, Edwin R; Tchakarov, Amanda; Yang, Chao; Li, Yisheng; Long, James P; Yee, Cassian; Lin, Jamie S

Singh, Shailbala; Clemente, Leticia C; Parra, Edwin R; Tchakarov, Amanda; Yang, Chao; Li, Yisheng; Long, James P; Yee, Cassian; Lin, Jamie S.

Afiliação

Singh S; Department of Melanoma Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Clemente LC; Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Parra ER; Department of Translational Molecular Pathology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Tchakarov A; Department of Pathology and Laboratory Medicine, University of Texas Health Science Center McGovern Medical School, Houston, TX, USA.
Yang C; Department of Biostatistics, Division of Basic Sciences, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Li Y; Department of Biostatistics, Division of Basic Sciences, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Long JP; Department of Biostatistics, Division of Basic Sciences, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Yee C; Department of Melanoma Medical Oncology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Lin JS; Department of Immunology, the University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Oncoimmunology ; 11(1): 2124678, 2022.

Article em En | MEDLINE | ID: mdl-36185804

Assuntos

Injúria Renal Aguda; Nefrite; Injúria Renal Aguda/induzido quimicamente; Injúria Renal Aguda/diagnóstico; Injúria Renal Aguda/tratamento farmacológico; Humanos; Inibidores de Checkpoint Imunológico/efeitos adversos; Rim/patologia; Nefrite/induzido quimicamente; Nefrite/diagnóstico; Nefrite/tratamento farmacológico; Linfócitos T

Palavras-chave

Immune checkpoint inhibitor; T cell receptor clonotype; acute interstitial nephritis; acute kidney injury; immune nephritis; immune-related adverse event; urinary immune cells

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Injúria Renal Aguda / Nefrite Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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