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The neuroanatomy of social trust predicts depression vulnerability.
Fermin, Alan S R; Kiyonari, Toko; Matsumoto, Yoshie; Takagishi, Haruto; Li, Yang; Kanai, Ryota; Sakagami, Masamichi; Akaishi, Rei; Ichikawa, Naho; Takamura, Masahiro; Yokoyama, Satoshi; Machizawa, Maro G; Chan, Hui-Ling; Matani, Ayumu; Yamawaki, Shigeto; Okada, Go; Okamoto, Yasumasa; Yamagishi, Toshio.
Afiliação
  • Fermin ASR; Center for Brain, Mind and Kansei Sciences Research, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Hiroshima, 734-8553, Japan. fermin@hiroshima-u.ac.jp.
  • Kiyonari T; Department of Neuroinformatics, Araya Inc., Tokyo, Japan. fermin@hiroshima-u.ac.jp.
  • Matsumoto Y; School of Social Informatics, Aoyama Gakuin University, Kanagawa, Japan.
  • Takagishi H; Brain Science Institute, Tamagawa University, Tokyo, Japan.
  • Li Y; Brain Science Institute, Tamagawa University, Tokyo, Japan.
  • Kanai R; Brain Science Institute, Tamagawa University, Tokyo, Japan.
  • Sakagami M; Department of Neuroinformatics, Araya Inc., Tokyo, Japan.
  • Akaishi R; Brain Science Institute, Tamagawa University, Tokyo, Japan.
  • Ichikawa N; Social Value Decision Making Unit, Riken Center for Brain Science, Saitama, Japan.
  • Takamura M; Center for Brain, Mind and Kansei Sciences Research, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Hiroshima, 734-8553, Japan.
  • Yokoyama S; Center for Brain, Mind and Kansei Sciences Research, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Hiroshima, 734-8553, Japan.
  • Machizawa MG; Department of Psychiatry and Neurosciences, Hiroshima University, Hiroshima, Japan.
  • Chan HL; Center for Brain, Mind and Kansei Sciences Research, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Hiroshima, 734-8553, Japan.
  • Matani A; Center for Brain, Mind and Kansei Sciences Research, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Hiroshima, 734-8553, Japan.
  • Yamawaki S; Center for Brain, Mind and Kansei Sciences Research, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Hiroshima, 734-8553, Japan.
  • Okada G; Center for Brain, Mind and Kansei Sciences Research, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Hiroshima, 734-8553, Japan.
  • Okamoto Y; Department of Psychiatry and Neurosciences, Hiroshima University, Hiroshima, Japan.
  • Yamagishi T; Department of Psychiatry and Neurosciences, Hiroshima University, Hiroshima, Japan.
Sci Rep ; 12(1): 16724, 2022 10 06.
Article em En | MEDLINE | ID: mdl-36202831
Trust attitude is a social personality trait linked with the estimation of others' trustworthiness. Trusting others, however, can have substantial negative effects on mental health, such as the development of depression. Despite significant progress in understanding the neurobiology of trust, whether the neuroanatomy of trust is linked with depression vulnerability remains unknown. To investigate a link between the neuroanatomy of trust and depression vulnerability, we assessed trust and depressive symptoms and employed neuroimaging to acquire brain structure data of healthy participants. A high depressive symptom score was used as an indicator of depression vulnerability. The neuroanatomical results observed with the healthy sample were validated in a sample of clinically diagnosed depressive patients. We found significantly higher depressive symptoms among low trusters than among high trusters. Neuroanatomically, low trusters and depressive patients showed similar volume reduction in brain regions implicated in social cognition, including the dorsolateral prefrontal cortex (DLPFC), dorsomedial PFC, posterior cingulate, precuneus, and angular gyrus. Furthermore, the reduced volume of the DLPFC and precuneus mediated the relationship between trust and depressive symptoms. These findings contribute to understanding social- and neural-markers of depression vulnerability and may inform the development of social interventions to prevent pathological depression.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Confiança / Depressão Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Encéfalo / Confiança / Depressão Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article