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Costunolide is a dual inhibitor of MEK1 and AKT1/2 that overcomes osimertinib resistance in lung cancer.
Tian, Xueli; Wang, Rui; Gu, Tingxuan; Ma, Fayang; Laster, Kyle Vaughn; Li, Xiang; Liu, Kangdong; Lee, Mee-Hyun; Dong, Zigang.
Afiliação
  • Tian X; Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, 450001, Zhengzhou, Henan, China.
  • Wang R; China-US (Henan) Hormel Cancer Institute, No.127, Dongming Road, Jinshui District, 450008, Zhengzhou, Henan, China.
  • Gu T; China-US (Henan) Hormel Cancer Institute, No.127, Dongming Road, Jinshui District, 450008, Zhengzhou, Henan, China.
  • Ma F; Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, 450001, Zhengzhou, Henan, China.
  • Laster KV; China-US (Henan) Hormel Cancer Institute, No.127, Dongming Road, Jinshui District, 450008, Zhengzhou, Henan, China.
  • Li X; Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, 450001, Zhengzhou, Henan, China.
  • Liu K; China-US (Henan) Hormel Cancer Institute, No.127, Dongming Road, Jinshui District, 450008, Zhengzhou, Henan, China.
  • Lee MH; China-US (Henan) Hormel Cancer Institute, No.127, Dongming Road, Jinshui District, 450008, Zhengzhou, Henan, China.
  • Dong Z; Department of Pathophysiology, School of Basic Medical Sciences, Zhengzhou University, 450001, Zhengzhou, Henan, China.
Mol Cancer ; 21(1): 193, 2022 10 06.
Article em En | MEDLINE | ID: mdl-36203195
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores ErbB / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores ErbB / Neoplasias Pulmonares Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article