Differential role of Pax6 and its interaction with Shh-Gli1-IDH2 axis in regulation of glioma growth and chemoresistance.

Farheen, Shirin; Ahmed, Swalih P; Mariyath P M, Mubeena; Kausar, Tasneem; Hoda, Md Fakhrul; Arif, Sayeedul H; Nayeem, Shahid M; Ali, Asif; Chosdol, Kunzang; Shahi, Mehdi H

Farheen, Shirin; Ahmed, Swalih P; Mariyath P M, Mubeena; Kausar, Tasneem; Hoda, Md Fakhrul; Arif, Sayeedul H; Nayeem, Shahid M; Ali, Asif; Chosdol, Kunzang; Shahi, Mehdi H.

Afiliação

Farheen S; Interdisciplinary Brain Research Centre, J.N. Medical College, Faculty of Medicine, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
Ahmed SP; Interdisciplinary Brain Research Centre, J.N. Medical College, Faculty of Medicine, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
Mariyath P M M; Interdisciplinary Brain Research Centre, J.N. Medical College, Faculty of Medicine, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
Kausar T; Department of Chemistry, Faculty of Sciences, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
Hoda MF; Department of Neuro Surgery, J.N. Medical College, Faculty of Medicine, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
Arif SH; Department of Pathology, J.N. Medical College, Faculty of Medicine, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
Nayeem SM; Department of Chemistry, Faculty of Sciences, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
Ali A; Interdisciplinary Brain Research Centre, J.N. Medical College, Faculty of Medicine, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
Chosdol K; Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India.
Shahi MH; Interdisciplinary Brain Research Centre, J.N. Medical College, Faculty of Medicine, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

J Biochem Mol Toxicol ; 37(2): e23241, 2023 Feb.

Article em En | MEDLINE | ID: mdl-36205257

Assuntos

Neoplasias Encefálicas; Glioma; Humanos; Proteína GLI1 em Dedos de Zinco/genética; Proteína GLI1 em Dedos de Zinco/metabolismo; Proteína GLI1 em Dedos de Zinco/uso terapêutico; Resistencia a Medicamentos Antineoplásicos; Proteínas Hedgehog/metabolismo; Glioma/tratamento farmacológico; Glioma/metabolismo; Neoplasias Encefálicas/metabolismo; Temozolomida/farmacologia; Fator de Transcrição PAX6/genética

Palavras-chave

Gli1; IDH2; Pax6; Shh; glioma; molecular dynamic simulation (MDS); protein docking

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Glioma Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Glioma Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article