UCMSCs-derived exosomal circHIPK3 promotes ulcer wound angiogenesis of diabetes mellitus via miR-20b-5p/Nrf2/VEGFA axis.

Liang, Zun-Hong; Lin, Shi-Shuai; Pan, Nan-Fang; Zhong, Guo-Yu; Qiu, Zhi-Yang; Kuang, Shao-Jia; Lin, Zhi-Hu; Zhang, Zhi; Pan, Yun-Chuan

Liang, Zun-Hong; Lin, Shi-Shuai; Pan, Nan-Fang; Zhong, Guo-Yu; Qiu, Zhi-Yang; Kuang, Shao-Jia; Lin, Zhi-Hu; Zhang, Zhi; Pan, Yun-Chuan.

Afiliação

Liang ZH; Department of Burn & Skin Repair Surgery, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, People's Republic of China.
Lin SS; Department of Burn & Skin Repair Surgery, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, People's Republic of China.
Pan NF; Department of Burn & Skin Repair Surgery, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, People's Republic of China.
Zhong GY; Department of Burn & Skin Repair Surgery, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, People's Republic of China.
Qiu ZY; Department of Burn & Skin Repair Surgery, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, People's Republic of China.
Kuang SJ; Department of Burn & Skin Repair Surgery, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, People's Republic of China.
Lin ZH; Department of Burn & Skin Repair Surgery, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, People's Republic of China.
Zhang Z; Department of Burn and Plastic Surgery, Guangzhou Red Cross Hospital Affifiliated to Jinan University, Guangzhou, People's Republic of China.
Pan YC; Department of Burn & Skin Repair Surgery, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou, People's Republic of China.

Diabet Med ; 40(2): e14968, 2023 02.

Article em En | MEDLINE | ID: mdl-36209373

Assuntos

Diabetes Mellitus Tipo 2; MicroRNAs; Humanos; Camundongos; Animais; MicroRNAs/genética; MicroRNAs/metabolismo; MicroRNAs/farmacologia; Fator 2 Relacionado a NF-E2/genética; Fator 2 Relacionado a NF-E2/metabolismo; Fator 2 Relacionado a NF-E2/farmacologia; Diabetes Mellitus Tipo 2/complicações; Diabetes Mellitus Tipo 2/genética; Diabetes Mellitus Tipo 2/metabolismo; Células Endoteliais da Veia Umbilical Humana/metabolismo; Proliferação de Células/genética; Fator A de Crescimento do Endotélio Vascular

Palavras-chave

Asian diabetes; UCMSCs; circHIPK3; exosome; foot ulcer; miR-20b-5p; revascularization

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: MicroRNAs / Diabetes Mellitus Tipo 2 Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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