Danshen injection induces autophagy in podocytes to alleviate nephrotic syndrome via the PI3K/AKT/mTOR pathway.

Chen, Junqi; Yuan, Shengliang; Zhou, Jie; Huang, Xiuye; Wu, Wenjia; Cao, Yiwen; Liu, Hong; Hu, Qinghong; Li, Xiaojie; Guan, Xueping; Yin, Simin; Jiang, Jiaying; Zhou, Yuan; Zhou, Jiuyao

Chen, Junqi; Yuan, Shengliang; Zhou, Jie; Huang, Xiuye; Wu, Wenjia; Cao, Yiwen; Liu, Hong; Hu, Qinghong; Li, Xiaojie; Guan, Xueping; Yin, Simin; Jiang, Jiaying; Zhou, Yuan; Zhou, Jiuyao.

Afiliação

Chen J; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangdong, China.
Yuan S; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangdong, China.
Zhou J; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangdong, China.
Huang X; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangdong, China.
Wu W; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangdong, China.
Cao Y; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangdong, China.
Liu H; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangdong, China.
Hu Q; The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangdong, China.
Li X; The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangdong, China.
Guan X; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangdong, China.
Yin S; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangdong, China.
Jiang J; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangdong, China.
Zhou Y; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangdong, China. Electronic address: zygz@gzucm.edu.cn.
Zhou J; School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangdong, China. Electronic address: zhoujiuyao@tom.com.

Phytomedicine ; 107: 154477, 2022 Dec.

Article em En | MEDLINE | ID: mdl-36215790

Assuntos

Síndrome Nefrótica; Podócitos; Salvia miltiorrhiza; Animais; Autofagia; Proteína Beclina-1/metabolismo; Caspase 3/metabolismo; Cloroquina/farmacologia; Creatinina; Desmina/metabolismo; Desmina/farmacologia; Doxorrubicina/farmacologia; Amarelo de Eosina-(YS)/metabolismo; Amarelo de Eosina-(YS)/farmacologia; Hematoxilina/metabolismo; Hematoxilina/farmacologia; Lipopolissacarídeos/farmacologia; Mamíferos/metabolismo; Camundongos; Proteínas Associadas aos Microtúbulos/metabolismo; Síndrome Nefrótica/induzido quimicamente; Síndrome Nefrótica/tratamento farmacológico; Síndrome Nefrótica/metabolismo; Ácido Periódico/metabolismo; Ácido Periódico/farmacologia; Fosfatidilinositol 3-Quinase/metabolismo; Fosfatidilinositol 3-Quinases/metabolismo; Podócitos/metabolismo; Prednisona/metabolismo; Prednisona/farmacologia; Proteínas Proto-Oncogênicas c-akt/metabolismo; Sirolimo/farmacologia; Serina-Treonina Quinases TOR/metabolismo

Palavras-chave

Danshen injection; Nephrotic syndrome; PI3K/AKT/mTOR pathway; Podocytes, Autophagy

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Salvia miltiorrhiza / Podócitos / Síndrome Nefrótica Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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