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Passive exposure to electronic cigarette aerosol in pregnancy: A case study of a family.
Ballbè, Montse; Fu, Marcela; Masana, Guillem; Pérez-Ortuño, Raúl; Gual, Antoni; Gil, Fernando; Olmedo, Pablo; García-Algar, Óscar; Pascual, Jose Antonio; Fernández, Esteve.
Afiliação
  • Ballbè M; Tobacco Control Unit, Cancer Control and Prevention Program, WHO Collaborating Center for Tobacco Control, Institut Català d'Oncologia (ICO), Av. Gran Via de l'Hospitalet 199-203, 08908, L'Hospitalet de Llobregat (Barcelona), Spain; Tobacco Control Research Group, Institut d'Investigació Biomèdica d
  • Fu M; Tobacco Control Unit, Cancer Control and Prevention Program, WHO Collaborating Center for Tobacco Control, Institut Català d'Oncologia (ICO), Av. Gran Via de l'Hospitalet 199-203, 08908, L'Hospitalet de Llobregat (Barcelona), Spain; Tobacco Control Research Group, Institut d'Investigació Biomèdica d
  • Masana G; Barcelona Clinic Schizophrenia Unit, Department of Psychiatry and Psychology, Institute of Neurosciences, Hospital Clínic de Barcelona, C. Villarroel 170, 08036, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; CIBER of Mental Health (CIBERSAM),
  • Pérez-Ortuño R; Group of Integrative Pharmacology and Systems Neuroscience, Neurosciences Programme, IMIM (Hospital del Mar Medical Research Institute), Parc de Recerca Biomèdica de Barcelona, Barcelona, Spain. Electronic address: rperez@imim.es.
  • Gual A; Grup de Recerca en Addiccions Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. Electronic address: tgual@clinic.cat.
  • Gil F; Department of Legal Medicine and Toxicology, School of Medicine, Universidad de Granada, Granada, Spain. Electronic address: fgil@ugr.es.
  • Olmedo P; Department of Legal Medicine and Toxicology, School of Medicine, Universidad de Granada, Granada, Spain. Electronic address: polmedopalma@ugr.es.
  • García-Algar Ó; Neonatology Unit, ICGON, Hospital Clínic-Maternitat, BCNatal, Barcelona, Spain. Electronic address: ogarciaa@clinic.cat.
  • Pascual JA; Group of Integrative Pharmacology and Systems Neuroscience, Neurosciences Programme, IMIM (Hospital del Mar Medical Research Institute), Parc de Recerca Biomèdica de Barcelona, Barcelona, Spain; Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona Biomedical Research Park, B
  • Fernández E; Tobacco Control Unit, Cancer Control and Prevention Program, WHO Collaborating Center for Tobacco Control, Institut Català d'Oncologia (ICO), Av. Gran Via de l'Hospitalet 199-203, 08908, L'Hospitalet de Llobregat (Barcelona), Spain; Tobacco Control Research Group, Institut d'Investigació Biomèdica d
Environ Res ; 216(Pt 1): 114490, 2023 01 01.
Article em En | MEDLINE | ID: mdl-36220444
ABSTRACT

BACKGROUND:

Passive exposure to the aerosols of electronic cigarettes (e-cigarettes) has been little studied. We assessed this exposure in late pregnancy in a woman and her 3-year-old child, exposed through e-cigarette use by another household member.

METHODS:

This prospective longitudinal case study involved a family unit consisting of an e-cigarette user, a pregnant woman who delivered an infant during the study, and the couple's older 3-year-old son. At 31, 36, and 40 weeks of the pregnancy, we measured biomarkers (nicotine metabolites, tobacco-specific nitrosamines, propanediols, glycerol, and metals) in the urine and hair of all three participants and in the saliva of the adults, in cord blood at delivery, and in the breast milk at the postpartum period.

RESULTS:

Samples from the e-cigarette user showed quantifiable concentrations of all analytes assessed (maximum urinary cotinine concentration, 4.9 ng/mL). Among samples taken from the mother, nicotine and its metabolites were found mainly in urine and also in saliva and hair, but not in cord blood. During the postpartum period, we found cotinine concentrations of 2.2 ng/mL in the mother's urine and 0.22 ng/mL in breast milk; 1,2-propanediol was generally detected in urine and saliva, but not in cord blood or breast milk. The maximum urinary cotinine concentration in the 3-year-old child was 2.6 ng/mL and propanediols also were detected in his urine. Nitrosamines were not detected in samples taken from the mother or the 3-year-old. Metals found in the refill liquid were detected at low levels in both the mother and the 3-year-old.

CONCLUSIONS:

We detected low but not negligible concentrations of e-cigarette-related analytes (including cord blood and breast milk) in an exposed pregnant non-user and in a 3-year-old child also living in the home. Passive exposure to e-cigarette aerosols cannot be disregarded and should be assessed in larger observational studies.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Poluição por Fumaça de Tabaco / Sistemas Eletrônicos de Liberação de Nicotina / Nitrosaminas Limite: Adult / Child, preschool / Female / Humans / Pregnancy Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Poluição por Fumaça de Tabaco / Sistemas Eletrônicos de Liberação de Nicotina / Nitrosaminas Limite: Adult / Child, preschool / Female / Humans / Pregnancy Idioma: En Ano de publicação: 2023 Tipo de documento: Article