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BDK inhibition acts as a catabolic switch to mimic fasting and improve metabolism in mice.
Bollinger, Eliza; Peloquin, Matthew; Libera, Jenna; Albuquerque, Bina; Pashos, Evanthia; Shipstone, Arun; Hadjipanayis, Angela; Sun, Zhongyuan; Xing, Gang; Clasquin, Michelle; Stansfield, John C; Tierney, Brendan; Gernhardt, Steven; Siddall, C Parker; Greizer, Timothy; Geoly, Frank J; Vargas, Sarah R; Gao, Lily C; Williams, George; Marshall, Mackenzie; Rosado, Amy; Steppan, Claire; Filipski, Kevin J; Zhang, Bei B; Miller, Russell A; Roth Flach, Rachel J.
Afiliação
  • Bollinger E; Internal Medicine Research Unit, Pfizer Inc, Cambridge MA 02139, USA.
  • Peloquin M; Internal Medicine Research Unit, Pfizer Inc, Cambridge MA 02139, USA.
  • Libera J; Internal Medicine Research Unit, Pfizer Inc, Cambridge MA 02139, USA.
  • Albuquerque B; Internal Medicine Research Unit, Pfizer Inc, Cambridge MA 02139, USA.
  • Pashos E; Internal Medicine Research Unit, Pfizer Inc, Cambridge MA 02139, USA.
  • Shipstone A; Inflammation & Immunology Research Unit, Pfizer Inc, Cambridge MA 02139, USA.
  • Hadjipanayis A; Inflammation & Immunology Research Unit, Pfizer Inc, Cambridge MA 02139, USA.
  • Sun Z; Internal Medicine Research Unit, Pfizer Inc, Cambridge MA 02139, USA.
  • Xing G; Internal Medicine Research Unit, Pfizer Inc, Cambridge MA 02139, USA.
  • Clasquin M; Internal Medicine Research Unit, Pfizer Inc, Cambridge MA 02139, USA.
  • Stansfield JC; Early Clinical Development, Pfizer Inc, Cambridge MA 02139, USA.
  • Tierney B; Medicine Design, Pfizer Inc, Groton, CT 06340, USA.
  • Gernhardt S; Medicine Design, Pfizer Inc, Groton, CT 06340, USA.
  • Siddall CP; Internal Medicine Research Unit, Pfizer Inc, Cambridge MA 02139, USA.
  • Greizer T; Internal Medicine Research Unit, Pfizer Inc, Cambridge MA 02139, USA.
  • Geoly FJ; Drug Safety Research and Development, Pfizer Inc, Groton CT 06340, USA.
  • Vargas SR; Drug Safety Research and Development, Pfizer Inc, Groton CT 06340, USA.
  • Gao LC; Internal Medicine Research Unit, Pfizer Inc, Cambridge MA 02139, USA.
  • Williams G; Internal Medicine Research Unit, Pfizer Inc, Cambridge MA 02139, USA.
  • Marshall M; Internal Medicine Research Unit, Pfizer Inc, Cambridge MA 02139, USA.
  • Rosado A; Medicine Design, Pfizer Inc, Groton, CT 06340, USA.
  • Steppan C; Medicine Design, Pfizer Inc, Groton, CT 06340, USA.
  • Filipski KJ; Medicine Design, Pfizer Inc, Cambridge MA 02139, USA.
  • Zhang BB; Internal Medicine Research Unit, Pfizer Inc, Cambridge MA 02139, USA.
  • Miller RA; Internal Medicine Research Unit, Pfizer Inc, Cambridge MA 02139, USA.
  • Roth Flach RJ; Internal Medicine Research Unit, Pfizer Inc, Cambridge MA 02139, USA. Electronic address: rachel.rothflach@pfizer.com.
Mol Metab ; 66: 101611, 2022 12.
Article em En | MEDLINE | ID: mdl-36220546
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: PPAR alfa / Fígado Gorduroso Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: PPAR alfa / Fígado Gorduroso Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article