Surface-Induced Protein Aggregation and Particle Formation in Biologics: Current Understanding of Mechanisms, Detection and Mitigation Strategies.

Kopp, Marie R G; Grigolato, Fulvio; Zürcher, Dominik; Das, Tapan K; Chou, Danny; Wuchner, Klaus; Arosio, Paolo

Kopp, Marie R G; Grigolato, Fulvio; Zürcher, Dominik; Das, Tapan K; Chou, Danny; Wuchner, Klaus; Arosio, Paolo.

Afiliação

Kopp MRG; Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland.
Grigolato F; Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland.
Zürcher D; Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland.
Das TK; Bristol Myers Squibb, Warren, NJ, USA.
Chou D; Compassion Biosolution, Lomita, CA, USA.
Wuchner K; Janssen Cilag AG, Schaffhausen, Switzerland.
Arosio P; Department of Chemistry and Applied Biosciences, ETH Zurich, Zurich, Switzerland. Electronic address: paolo.arosio@chem.ethz.ch.

J Pharm Sci ; 112(2): 377-385, 2023 02.

Article em En | MEDLINE | ID: mdl-36223809

Assuntos

Produtos Biológicos; Agregados Proteicos; Química Farmacêutica/métodos; Proteínas de Membrana; Água

Palavras-chave

Antibodies; Formulation; Particles; Protein aggregation; Surface

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Produtos Biológicos / Agregados Proteicos Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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