Reactivation of Vertebral Growth Plate Function in Vertebral Body Tethering in an Animal Model.
Int J Mol Sci
; 23(19)2022 Sep 30.
Article
em En
| MEDLINE
| ID: mdl-36232897
ABSTRACT
Flexible spine tethering is a relatively novel fusionless surgical technique that aims to correct scoliosis based on growth modulation due to the pressure exerted on the vertebral body epiphyseal growth plate. The correction occurs in two phases immediate intraoperative and postoperative with growth. The aim of this study was to evaluate the reactivation of vertebral growth plate function after applying corrective forces. The rat tail model was used. Asymmetric compression and distraction of caudal growth plates were performed using a modified external fixation apparatus. Radiological and histopathological data were analysed. After three weeks of correction, the activity of the structures increased across the entire growth plate width, and the plate was thickened. The height of the hypertrophic layer and chondrocytes on the concave side doubled in height. The height of chondrocytes and the cartilage thickness on the concave and central sides after the correction did not differ statistically significantly from the control group. Initiation of the correction of scoliosis in the growing spine, with relief of the pressure on the growth plate, allows the return of the physiological activity of the growth cartilage and restoration of the deformed vertebral body.
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Base de dados:
MEDLINE
Assunto principal:
Escoliose
Limite:
Animals
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article