New Oxazolo[5,4-<i>d</i>]pyrimidines as Potential Anticancer Agents: Their Design, Synthesis, and In Vitro Biological Activity Research.

Sochacka-Cwikla, Aleksandra; Maczynski, Marcin; Czyznikowska, Zaneta; Wiatrak, Benita; Jeskowiak, Izabela; Czerski, Albert; Regiec, Andrzej

New Oxazolo[5,4-d]pyrimidines as Potential Anticancer Agents: Their Design, Synthesis, and In Vitro Biological Activity Research.

Sochacka-Cwikla, Aleksandra; Maczynski, Marcin; Czyznikowska, Zaneta; Wiatrak, Benita; Jeskowiak, Izabela; Czerski, Albert; Regiec, Andrzej.

Afiliação

Sochacka-Cwikla A; Department of Organic Chemistry and Drug Technology, Faculty of Pharmacy, Wroclaw Medical University, 211A Borowska Street, 50-556 Wroclaw, Poland.
Maczynski M; Department of Organic Chemistry and Drug Technology, Faculty of Pharmacy, Wroclaw Medical University, 211A Borowska Street, 50-556 Wroclaw, Poland.
Czyznikowska Z; Department of Inorganic Chemistry, Faculty of Pharmacy, Wroclaw Medical University, 211A Borowska Street, 50-556 Wroclaw, Poland.
Wiatrak B; Department of Pharmacology, Faculty of Medicine, Wroclaw Medical University, 2 Mikulicza-Radeckiego Street, 50-345 Wroclaw, Poland.
Jeskowiak I; Department of Pharmacology, Faculty of Medicine, Wroclaw Medical University, 2 Mikulicza-Radeckiego Street, 50-345 Wroclaw, Poland.
Czerski A; Department of Biostructure and Animal Physiology, Wroclaw University of Environmental and Life Sciences, 25/27 Norwida Street, 50-375 Wroclaw, Poland.
Regiec A; Department of Organic Chemistry and Drug Technology, Faculty of Pharmacy, Wroclaw Medical University, 211A Borowska Street, 50-556 Wroclaw, Poland.

Int J Mol Sci ; 23(19)2022 Oct 02.

Article em En | MEDLINE | ID: mdl-36232997

Assuntos

Adenocarcinoma; Antineoplásicos; Neoplasias do Colo; Subfamília B de Transportador de Cassetes de Ligação de ATP/metabolismo; Antineoplásicos/química; Proliferação de Células; Cisplatino/farmacologia; Relação Dose-Resposta a Droga; Ensaios de Seleção de Medicamentos Antitumorais; Fluoruracila/farmacologia; Humanos; Isoxazóis/farmacologia; Simulação de Acoplamento Molecular; Estrutura Molecular; Purinas/farmacologia; Pirimidinas/química; Relação Estrutura-Atividade; Fator A de Crescimento do Endotélio Vascular/metabolismo; Receptor 2 de Fatores de Crescimento do Endotélio Vascular/metabolismo

Palavras-chave

VEGFR-2 inhibitors; anticancer activity; antimetabolites; cytotoxicity; isoxazole; molecular docking; oxazolo[5,4-d]pyrimidines

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Adenocarcinoma / Neoplasias do Colo / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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