Peptide-based covalent inhibitors of protein-protein interactions.
J Pept Sci
; 29(1): e3457, 2023 Jan.
Article
em En
| MEDLINE
| ID: mdl-36239115
ABSTRACT
Protein-protein interactions (PPI) are involved in all cellular processes and many represent attractive therapeutic targets. However, the frequently rather flat and large interaction areas render the identification of small molecular PPI inhibitors very challenging. As an alternative, peptide interaction motifs derived from a PPI interface can serve as starting points for the development of inhibitors. However, certain proteins remain challenging targets when applying inhibitors with a competitive mode of action. For that reason, peptide-based ligands with an irreversible binding mode have gained attention in recent years. This review summarizes examples of covalent inhibitors that employ peptidic binders and have been tested in a biological context.
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article