Development of an Open Face Home Cage Running Wheel for Testing Activity-Based Anorexia and Other Applications.
eNeuro
; 9(5)2022.
Article
em En
| MEDLINE
| ID: mdl-36241420
ABSTRACT
Running wheels for mice residing in the home cage are useful for the continuous measurement of locomotor activity for studies testing exercise interventions or exercise-induced effects on brain and metabolism. Here, we have developed an open source, printable, open-faced running wheel that is automated to collect locomotor information such as distance traveled, wheel direction, and velocity that can be binned into epochs over 24 h or multiple days. This system allows for remote data collection to avoid human interference in mouse behavioral experiments. We tested this system in an activity-based anorexia procedure. Using these wheels, we replicate previous findings that food restriction augments wheel-running activity.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Anorexia
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Atividade Motora
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article