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RABC: Rheumatoid Arthritis Bioinformatics Center.
Chen, Haiyan; Xu, Jing; Wei, Siyu; Jia, Zhe; Sun, Chen; Kang, Jingxuan; Guo, Xuying; Zhang, Nan; Tao, Junxian; Dong, Yu; Zhang, Chen; Ma, Yingnan; Lv, Wenhua; Tian, Hongsheng; Bi, Shuo; Lv, Hongchao; Huang, Chen; Kong, Fanwu; Tang, Guoping; Jiang, Yongshuai; Zhang, Mingming.
Afiliação
  • Chen H; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
  • Xu J; The ABC Project, Harbin, China.
  • Wei S; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
  • Jia Z; The ABC Project, Harbin, China.
  • Sun C; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
  • Kang J; The ABC Project, Harbin, China.
  • Guo X; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
  • Zhang N; The ABC Project, Harbin, China.
  • Tao J; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
  • Dong Y; The ABC Project, Harbin, China.
  • Zhang C; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
  • Ma Y; The ABC Project, Harbin, China.
  • Lv W; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
  • Tian H; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
  • Bi S; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
  • Lv H; The ABC Project, Harbin, China.
  • Huang C; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
  • Kong F; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
  • Tang G; The ABC Project, Harbin, China.
  • Jiang Y; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
  • Zhang M; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China.
Nucleic Acids Res ; 51(D1): D1381-D1387, 2023 01 06.
Article em En | MEDLINE | ID: mdl-36243962
ABSTRACT
Advances in sequencing technologies have led to the rapid growth of multi-omics data on rheumatoid arthritis (RA). However, a comprehensive database that systematically collects and classifies the scattered data is still lacking. Here, we developed the Rheumatoid Arthritis Bioinformatics Center (RABC, http//www.onethird-lab.com/RABC/), the first multi-omics data resource platform (data hub) for RA. There are four categories of data in RABC (i) 175 multi-omics sample sets covering transcriptome, epigenome, genome, and proteome; (ii) 175 209 differentially expressed genes (DEGs), 105 differentially expressed microRNAs (DEMs), 18 464 differentially DNA methylated (DNAm) genes, 1 764 KEGG pathways, 30 488 GO terms, 74 334 SNPs, 242 779 eQTLs, 105 m6A-SNPs and 18 491 669 meta-mQTLs; (iii) prior knowledge on seven types of RA molecular markers from nine public and credible databases; (iv) 127 073 literature information from PubMed (from 1972 to March 2022). RABC provides a user-friendly interface for browsing, searching and downloading these data. In addition, a visualization module also supports users to generate graphs of analysis results by inputting personalized parameters. We believe that RABC will become a valuable resource and make a significant contribution to the study of RA.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Bases de Dados Factuais Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Bases de Dados Factuais Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article