HCP5 prevents ubiquitination-mediated UTP3 degradation to inhibit apoptosis by activating c-Myc transcriptional activity.

Nan, Yabing; Luo, Qingyu; Wu, Xiaowei; Chang, Wan; Zhao, Pengfei; Liu, Shi; Liu, Zhihua

Nan, Yabing; Luo, Qingyu; Wu, Xiaowei; Chang, Wan; Zhao, Pengfei; Liu, Shi; Liu, Zhihua.

Afiliação

Nan Y; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Luo Q; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Wu X; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Chang W; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Zhao P; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Liu S; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Liu Z; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. Electronic address: liuzh@cicams.ac.cn.

Mol Ther ; 31(2): 552-568, 2023 02 01.

Article em En | MEDLINE | ID: mdl-36245126

Assuntos

Antineoplásicos; Neoplasias Esofágicas; Carcinoma de Células Escamosas do Esôfago; MicroRNAs; RNA Longo não Codificante; Humanos; Antineoplásicos/farmacologia; Antineoplásicos/uso terapêutico; Apoptose/genética; Linhagem Celular Tumoral; Proliferação de Células; Proteínas de Ligação a DNA/metabolismo; Neoplasias Esofágicas/genética; Carcinoma de Células Escamosas do Esôfago/tratamento farmacológico; Regulação Neoplásica da Expressão Gênica; MicroRNAs/genética; Recidiva Local de Neoplasia/genética; RNA Longo não Codificante/genética; RNA Longo não Codificante/metabolismo; Fatores de Transcrição/genética; Ubiquitinação; Proteína 3 Associada à Membrana da Vesícula/genética; Proteína 3 Associada à Membrana da Vesícula/metabolismo

Palavras-chave

UTP3 small subunit processome component (UTP3); apoptosis; c-Myc; chemoresistance; esophageal squamous cell carcinoma (ESCC); histocompatibility leukocyte antigen complex P5 (HCP5)

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Esofágicas / MicroRNAs / RNA Longo não Codificante / Carcinoma de Células Escamosas do Esôfago / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google