Dickkopf-1 as a promising therapeutic target for autoimmune diseases.
Clin Immunol
; 245: 109156, 2022 12.
Article
em En
| MEDLINE
| ID: mdl-36257529
ABSTRACT
Dickkopf-1 (DKK-1) is mostly known as a mature inhibitor of classic Wnt signaling pathways, which plays a critically role in regulating bone formation and bone metastasis. In recent years, the roles of DKK-1 played in bone resorption, bone formation, immune homeostasis and inflammation have been investigated. The role of DKK-1 in the pathogenesis and treatment of autoimmune diseases (ADs), including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), etc, has attracted widespread attention. Various studies have found that DKK-1 may be used as a biomarker for the occurrence and development of ADs, and as a potential target for the treatment of ADs. In this review, we have briefly summed up the intricate immunological functions and regulatory mechanisms of DKK-1 in ADs, aiming to further learning more about the role of DKK-1 involved in the pathogenesis of ADs and provide an outlook for the potential future researches.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Artrite Reumatoide
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Doenças Autoimunes
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Reabsorção Óssea
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Lúpus Eritematoso Sistêmico
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article