Nivolumab with or without chemotherapy for metastatic gastroesophageal cancers and future perspectives.
Expert Rev Anticancer Ther
; 22(11): 1177-1181, 2022 11.
Article
em En
| MEDLINE
| ID: mdl-36266061
ABSTRACT
INTRODUCTION:
Gastroesophageal cancers (GEC) are frequently found at the advanced stage. GEC treatment advancements have been limited and prognosis, therefore, remains poor. Through numerous clinical trials, the addition of immune checkpoint inhibitors, including nivolumab, to conventional therapy has demonstrated a survival benefit. AREAS COVERED Here, we focus on the function of nivolumab in patients with advanced GECs. We discuss the most recent trials that led to nivolumab's incorporation into therapy and pathways forward. EXPERT OPINION Nivolumab in combination with chemotherapy appears well tolerated, with only a small number of patients reporting severe toxicity; therefore, it may be possible to add additional biological agents to improve outcomes. A number of 'nivolumab plus other agents' is currently being investigated, and we anticipate continued advancement in GEC management in the coming years.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
/
Neoplasias Esofágicas
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article