Polyploid tubular cells and chronic kidney disease.
Kidney Int
; 102(5): 959-961, 2022 11.
Article
em En
| MEDLINE
| ID: mdl-36272751
ABSTRACT
Defective DNA repair drives chronic kidney disease (CKD), but mechanisms are unclear. Airik and colleagues use a genetic model of defective DNA repair mimicking karyomegalic nephritis, a form of CKD characterized by tubular epithelial cells (TEC) with large nuclei and tubulointerstitial nephritis. They show that DNA damage in TEC triggers endoreplication leading to polyploid TEC and CKD. Blocking endoreplication preserved kidney function, suggesting that DNA damage triggers CKD via TEC polyploidization, questioning the concept of G2/M-arrest.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Insuficiência Renal Crônica
/
Nefrite
/
Nefrite Intersticial
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article