Biology and postnatal development of organ systems of cynomolgus monkeys (Macaca fascicularis).
J Med Primatol
; 52(1): 64-78, 2023 02.
Article
em En
| MEDLINE
| ID: mdl-36300896
ABSTRACT
BACKGROUND:
The cynomolgus macaque has become the most used non-human primate species in nonclinical safety assessment during the past decades.METHODS:
This review summarizes the biological data and organ system development milestones of the cynomolgus macaque available in the literature.RESULTS:
The cynomolgus macaque is born precocious relative to humans in some organ systems (e.g., nervous, skeletal, respiratory, and gastrointestinal). Organ systems develop, refine, and expand at different rates after birth. In general, the respiratory, gastrointestinal, renal, and hematopoietic systems mature at approximately 3 years of age. The female reproductive, cardiovascular and hepatobiliary systems mature at approximately 4 years of age. The central nervous, skeletal, immune, male reproductive, and endocrine systems complete their development at approximately 5 to 9 years of age.CONCLUSIONS:
The cynomolgus macaque has no meaningful developmental differences in critical organ systems between 2 and 3 years of age for use in nonclinical safety assessment.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Biologia
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article