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Models of bilirubin neurological damage: lessons learned and new challenges.
Gazzin, Silvia; Jayanti, Sri; Tiribelli, Claudio.
Afiliação
  • Gazzin S; Fondazione Italiana Fegato-Onlus, Bldg. Q, AREA Science Park, ss14, Km 163.5, Basovizza, Trieste, 34149, Italy. silvia.gazzin@fegato.it.
  • Jayanti S; Fondazione Italiana Fegato-Onlus, Bldg. Q, AREA Science Park, ss14, Km 163.5, Basovizza, Trieste, 34149, Italy.
  • Tiribelli C; Molecular Biomedicine Ph.D. Program, University of Trieste, Trieste, 34127, Italy.
Pediatr Res ; 93(7): 1838-1845, 2023 Jun.
Article em En | MEDLINE | ID: mdl-36302856
OBJECTIVE: Jaundice (icterus) is the visible manifestation of the accumulation of bilirubin in the tissue and is indicative of potential toxicity to the brain. Since its very first description more than 2000 years ago, many efforts have been undertaken to understand the molecular determinants of bilirubin toxicity to neuronal cells to reduce the risk of neurological sequelae through the use of available chemicals and in vitro, ex vivo, in vivo, and clinical models. Although several studies have been performed, important questions remain unanswered, such as the reasons for regional sensitivity and the interplay with brain development. The number of new molecular effects identified has increased further, which has added even more complexity to the understanding of the condition. As new research challenges emerged, so does the need to establish solid models of prematurity. METHODS: This review critically summarizes the key mechanisms of severe neonatal hyperbilirubinemia and the use of the available models and technologies for translational research. IMPACT: We critically review the conceptual dogmas and models used for studying bilirubin-induced neurotoxicity. We point out the pitfalls and translational gaps, and suggest new clinical research challenges. We hope to inform researchers on the pro and cons of the models used, and to help direct their experimental focus in a most translational research.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndromes Neurotóxicas / Traumatismos do Sistema Nervoso / Hiperbilirrubinemia Neonatal / Icterícia Neonatal Limite: Humans / Newborn Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Síndromes Neurotóxicas / Traumatismos do Sistema Nervoso / Hiperbilirrubinemia Neonatal / Icterícia Neonatal Limite: Humans / Newborn Idioma: En Ano de publicação: 2023 Tipo de documento: Article