The Effect of Xylazine/Zoletil Anesthesia on the Radiosensitivity of Mice under Total Irradiation with X-Rays, Protons, and Carbon Ions.
Dokl Biochem Biophys
; 506(1): 185-190, 2022 Oct.
Article
em En
| MEDLINE
| ID: mdl-36303049
ABSTRACT
The effect of xylazine-zoletyl anesthesia on the radiosensitivity of mice irradiated with protons, carbon ions in two regions of the Bragg curve, and X-ray radiation was studied according to the criteria of 30-day survival, dynamics of death, and the average life span of dead mice. The maximum effect of anesthesia by 3.3 times was observed by a decrease in the death of animals during irradiation with carbon ions at the Bragg peak; in the case of irradiation before the peak, the effect was 1.2 times. In the case of proton irradiation at the Bragg peak, the protective effect of anesthesia by a factor of 1.7 was observed only at a dose of 8.5 Gy. When mice were irradiated with X-rays in the dose range of 6.0-8.5 Gy, the anesthesia effect coefficient was 1.7-2. According to the 30-day survival method, it was shown that the use of a xylazine-zoletil mixture significantly changes the radiosensitivity of mice depending on the radiation dose and the radiation source quality.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tolerância a Radiação
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Xilazina
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Relação Dose-Resposta à Radiação
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Anestesia
Limite:
Animals
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article