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Adult human kidney organoids originate from CD24+ cells and represent an advanced model for adult polycystic kidney disease.
Xu, Yaoxian; Kuppe, Christoph; Perales-Patón, Javier; Hayat, Sikander; Kranz, Jennifer; Abdallah, Ali T; Nagai, James; Li, Zhijian; Peisker, Fabian; Saritas, Turgay; Halder, Maurice; Menzel, Sylvia; Hoeft, Konrad; Kenter, Annegien; Kim, Hyojin; van Roeyen, Claudia R C; Lehrke, Michael; Moellmann, Julia; Speer, Thimoteus; Buhl, Eva M; Hoogenboezem, Remco; Boor, Peter; Jansen, Jitske; Knopp, Cordula; Kurth, Ingo; Smeets, Bart; Bindels, Eric; Reinders, Marlies E J; Baan, Carla; Gribnau, Joost; Hoorn, Ewout J; Steffens, Joachim; Huber, Tobias B; Costa, Ivan; Floege, Jürgen; Schneider, Rebekka K; Saez-Rodriguez, Julio; Freedman, Benjamin S; Kramann, Rafael.
Afiliação
  • Xu Y; Institute of Experimental Medicine and Systems Biology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
  • Kuppe C; Institute of Experimental Medicine and Systems Biology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
  • Perales-Patón J; Division of Nephrology and Clinical Immunology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
  • Hayat S; Institute of Experimental Medicine and Systems Biology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
  • Kranz J; Institute for Computational Biomedicine, Faculty of Medicine, Heidelberg University and Heidelberg University Hospital, Bioquant, Heidelberg, Germany.
  • Abdallah AT; Institute of Experimental Medicine and Systems Biology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
  • Nagai J; Institute of Experimental Medicine and Systems Biology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
  • Li Z; Department of Urology and Pediatric Urology, RWTH Aachen University, Aachen, Germany.
  • Peisker F; Department of Urology and Kidney Transplantation, Martin-Luther-University, Halle, Germany.
  • Saritas T; Interdisciplinary Center for Clinical Research, RWTH Aachen University, Aachen, Germany.
  • Halder M; Institute of Computational Genomics, RWTH Aachen University, Aachen, Germany.
  • Menzel S; Institute of Computational Genomics, RWTH Aachen University, Aachen, Germany.
  • Hoeft K; Institute of Experimental Medicine and Systems Biology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
  • Kenter A; Institute of Experimental Medicine and Systems Biology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
  • Kim H; Division of Nephrology and Clinical Immunology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
  • van Roeyen CRC; Institute of Experimental Medicine and Systems Biology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
  • Lehrke M; Institute of Experimental Medicine and Systems Biology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
  • Moellmann J; Institute of Experimental Medicine and Systems Biology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
  • Speer T; Division of Nephrology and Clinical Immunology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
  • Buhl EM; Department of Developmental Biology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
  • Hoogenboezem R; Department of Cell Biology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands.
  • Boor P; Department of Internal Medicine and Department of Nephrology and Transplantation, Erasmus Medical Center Transplant Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands.
  • Jansen J; Institute of Experimental Medicine and Systems Biology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
  • Knopp C; Institute of Experimental Medicine and Systems Biology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
  • Kurth I; Department of Cardiology, RWTH Aachen University, Aachen, Germany.
  • Smeets B; Department of Cardiology, RWTH Aachen University, Aachen, Germany.
  • Bindels E; Department of Nephrology, University Hospital Homburg, Homburg, Germany.
  • Reinders MEJ; Institute of Pathology and Electron Microscopy Facility, RWTH Aachen University, Aachen, Germany.
  • Baan C; Department of Hematology, Erasmus Medical Center, Rotterdam, the Netherlands.
  • Gribnau J; Division of Nephrology and Clinical Immunology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
  • Hoorn EJ; Institute of Pathology and Electron Microscopy Facility, RWTH Aachen University, Aachen, Germany.
  • Steffens J; Institute of Experimental Medicine and Systems Biology, Medical Faculty, RWTH Aachen University, Aachen, Germany.
  • Huber TB; Department of Pathology, RIMLS, Radboudumc, Nijmegen, the Netherlands.
  • Costa I; Institute of Human Genetics, RWTH Aachen University, Aachen, Germany.
  • Floege J; Institute of Human Genetics, RWTH Aachen University, Aachen, Germany.
  • Schneider RK; Department of Pathology, RIMLS, Radboudumc, Nijmegen, the Netherlands.
  • Saez-Rodriguez J; Department of Hematology, Erasmus Medical Center, Rotterdam, the Netherlands.
  • Freedman BS; Department of Internal Medicine and Department of Nephrology and Transplantation, Erasmus Medical Center Transplant Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands.
  • Kramann R; Department of Internal Medicine and Department of Nephrology and Transplantation, Erasmus Medical Center Transplant Institute, University Medical Center Rotterdam, Rotterdam, the Netherlands.
Nat Genet ; 54(11): 1690-1701, 2022 11.
Article em En | MEDLINE | ID: mdl-36303074
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Rim Policístico Autossômico Dominante / Cistos Limite: Adult / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Rim Policístico Autossômico Dominante / Cistos Limite: Adult / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article