The potential of biology-guided radiation therapy in thoracic cancer: A preliminary treatment planning study.

Seyedin, Steven N; Bassalow, Rostem; Mawlawi, Osama R; Turner, Lehendrick M; Patel, Roshal R; Mazin, Samuel R; Oderinde, Oluwaseyi M; Voronenko, Yevgen; Wages, Cody A; Olcott, Peter D; Chang, Joe Y; Balter, Peter A; Welsh, James W

Seyedin, Steven N; Bassalow, Rostem; Mawlawi, Osama R; Turner, Lehendrick M; Patel, Roshal R; Mazin, Samuel R; Oderinde, Oluwaseyi M; Voronenko, Yevgen; Wages, Cody A; Olcott, Peter D; Chang, Joe Y; Balter, Peter A; Welsh, James W.

Afiliação

Seyedin SN; Department of Radiation Oncology, University of California, Irvine-Chao Family Comprehensive Cancer Center, Orange, CA, United States.
Bassalow R; Northwest Medical Physics Center, Lynnwood, WA, United States.
Mawlawi OR; Department of Imaging Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Turner LM; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Patel RR; Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, United States.
Mazin SR; RefleXion Medical, Hayward, CA, United States.
Oderinde OM; RefleXion Medical, Hayward, CA, United States.
Voronenko Y; RefleXion Medical, Hayward, CA, United States.
Wages CA; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Olcott PD; RefleXion Medical, Hayward, CA, United States.
Chang JY; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Balter PA; Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.
Welsh JW; Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States.

Front Oncol ; 12: 921473, 2022.

Article em En | MEDLINE | ID: mdl-36313653

ABSTRACT

ABSTRACT

Purpose:

We investigated the feasibility of biology-guided radiotherapy (BgRT), a technique that utilizes real-time positron emission imaging to minimize tumor motion uncertainties, to spare nearby organs at risk.

Methods:

Volumetric modulated arc therapy (VMAT), intensity-modulated proton (IMPT) therapy, and BgRT plans were created for a paratracheal node recurrence (case 1; 60 Gy in 10 fractions) and a primary peripheral left upper lobe adenocarcinoma (case 2; 50 Gy in four fractions).

Results:

For case 1, BgRT produced lower bronchus V40 values compared to VMAT and IMPT. For case 2, total lung V20 was lower in the BgRT case compared to VMAT and IMPT.