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Immunoglobulin somatic hypermutation in a defined biochemical system recapitulates affinity maturation and permits antibody optimization.
Jeong, Soo Lim; Zhang, Hongyu; Yamaki, Shanni; Yang, Chenyu; McKemy, David D; Lieber, Michael R; Pham, Phuong; Goodman, Myron F.
Afiliação
  • Jeong SL; Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
  • Zhang H; Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
  • Yamaki S; Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
  • Yang C; Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
  • McKemy DD; Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
  • Lieber MR; Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
  • Pham P; Departments of Pathology, Biochemistry & Molecular Biology, and Molecular Microbiology & Immunology, Norris Comprehensive Cancer Center, University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA.
  • Goodman MF; Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA.
Nucleic Acids Res ; 50(20): 11738-11754, 2022 11 11.
Article em En | MEDLINE | ID: mdl-36321646
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hipermutação Somática de Imunoglobulina / Anticorpos de Cadeia Única / Anticorpos de Domínio Único Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hipermutação Somática de Imunoglobulina / Anticorpos de Cadeia Única / Anticorpos de Domínio Único Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article