Hypothyroidism Modeling in Wistar Rats: Comparison of Two Surgical Methods.
Bull Exp Biol Med
; 173(6): 794-800, 2022 Oct.
Article
em En
| MEDLINE
| ID: mdl-36322315
ABSTRACT
In this study we present 2 surgical models of hypothyroidism in male Wistar rats (n=80) based on total thyroidectomy. Animals weighing 180-200 g were randomly divided into sham-operated group and 2 experimental groups. Thyroidectomy was performed by 2 different methods:
primary ligation of either thyroid artery (TE-I) or vein (TE-II). The success of the model was verified through general postoperative conditions, serum hormone levels, histological study, and neck ultrasound. Hypothyroidism was successfully reproduced in both TE-I and TE-II models. TE-I was characterized by lower intra- and post-operative mortality, while TE-II provided better surgical exposure to the key anatomical sites.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Hipotireoidismo
Limite:
Animals
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article