The relationship of genetic risk score with cardiometabolic risk factors: a cross-sectional study.
BMC Cardiovasc Disord
; 22(1): 459, 2022 11 02.
Article
em En
| MEDLINE
| ID: mdl-36324080
BACKGROUND & AIMS: For more than eight decades, cardiovascular disease (CVD) has remained the leading cause of death in the world. CVD risk factors are multifaceted, with genetics and lifestyle both playing a role. The aim of this study was to investigate the association between a genetic profile risk score for obesity GRS and cardio-metabolic risk factors in overweight and obese women. METHODS: The current cross-sectional study was conducted on 391 overweight and obese women. The genetic risk score was created by combining three single nucleotide polymorphisms [MC4R (rs17782313), CAV-1 (rs3807992), and Cry-1 (rs2287161)]. Anthropometric measurements, blood pressure, and some blood parameters were measured by standard protocols. RESULTS: A significant association between the GRS and some of cardiometabolic risk factors variables such as body mass index (ß = 0. 49, 95%CI = 0.22 to 0.76, p < 0.001), waist circumference (ß = 0. 86, 95%CI = 0.18 to 1.54, p = 0.01), body fat mass (ß = 0. 82, 95%CI = 0.25 to 1.39, p = 0.005), %body fat (ß = 0. 44, 95%CI = 0.06 to 0.82, p = 0.02), and hs-CRP (ß = 0.46, 95% CI = 0.14 to 0.78, p = 0.005) was observed in crude model. After adjustment for confounding factors (age, BMI, and physical activity), a significant positive association was observed between BMI (p = 0.004), WC (p = 0.02), body fat mass (p = 0.01), %BF (p = 0.01), hs-CRP (p = 0.009), and GRS. In addition, we discovered a significant negative association between the GRS and BMC (= -0.02, 95%CI = -0.05 to -0.001, p = 0.04). But other variables did not show any significant association with GRS among obese and overweight women. CONCLUSION: We found a significant positive association between GRS, including MC4R (rs17782313), CAV-1 (rs3807992), and Cry-1 (rs2287161) and cardiometabolic risk factors among overweight and obese Iranian women.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Cardiovasculares
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Sobrepeso
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Female
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Humans
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article