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Real-Time Whole Genome Sequencing to Guide Patient-Tailored Therapy of Severe Acute Respiratory Syndrome Coronavirus 2 Infection.
Snell, Luke B; Alcolea-Medina, Adela; Charalampous, Themoula; Alder, Christopher; Williams, Tom G S; Flaviani, Flavia; Batra, Rahul; Bakrania, Prijay; Thangarajah, Rajeni; Neil, Stuart J D; van Nispen Tot Pannerden, Claire; Botgros, Alina; Aarons, Emma; Douthwaite, Samuel T; Edgeworth, Jonathan D; Nebbia, Gaia.
Afiliação
  • Snell LB; Department of Infection, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
  • Alcolea-Medina A; Department of Infection, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
  • Charalampous T; Department of Infection, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
  • Alder C; Department of Infection, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
  • Williams TGS; Department of Infection, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
  • Flaviani F; National Institute for Health Research Biomedical Research Centre, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
  • Batra R; Department of Infection, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
  • Bakrania P; Department of Pharmacy, Guy's and St Thomas' NHS Foundation Trust, London, UK.
  • Thangarajah R; Department of Infection, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
  • Neil SJD; Department of Pharmacy, Guy's and St Thomas' NHS Foundation Trust, London, UK.
  • van Nispen Tot Pannerden C; Department of Infectious Diseases, King's College London, United Kingdom.
  • Botgros A; Department of Infection, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
  • Aarons E; Department of Infection, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
  • Douthwaite ST; Department of Infection, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
  • Edgeworth JD; Department of Infection, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
  • Nebbia G; Department of Infection, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
Clin Infect Dis ; 76(6): 1125-1128, 2023 03 21.
Article em En | MEDLINE | ID: mdl-36327795
ABSTRACT
The management of coronavirus disease 2019 has become more complex due to the expansion of available therapies. The presence of severe acute respiratory syndrome coronavirus 2 variants and mutations further complicates treatment due to their differing susceptibilities to therapies. Here we outline the use of real-time whole genome sequencing to detect persistent infection, evaluate for mutations confering resistance to treatments, and guide treatment decisions.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: COVID-19 Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: COVID-19 Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article