Your browser doesn't support javascript.
loading
Cephalotane-type C20 diterpenoids from Cephalotaxus fortunei var. alpina.
Ge, Zhan-Peng; Zhou, Bin; Zimbres, Flavia M; Haney, Reagan S; Liu, Qun-Fang; Wu, Yan; Cassera, Maria B; Zhao, Jin-Xin; Yue, Jian-Min.
Afiliação
  • Ge ZP; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China. jmyue@simm.ac.cn.
  • Zhou B; Research Units of Discovery of New Drug Lead Molecules, Chinese Academy of Medical Sciences, Shanghai 201203, China.
  • Zimbres FM; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China. jmyue@simm.ac.cn.
  • Haney RS; Research Units of Discovery of New Drug Lead Molecules, Chinese Academy of Medical Sciences, Shanghai 201203, China.
  • Liu QF; Shandong Laboratory of Yantai Drug Discovery, Bohai Rim Advanced Research Institute for Drug Discovery, 198 East Binhai Road, Yantai, Shandong 264117, China.
  • Wu Y; Department of Biochemistry and Molecular Biology, Center for Tropical and Emerging Global Diseases (CTEGD), University of Georgia, Athens, Georgia 30602, USA.
  • Cassera MB; Department of Biochemistry and Molecular Biology, Center for Tropical and Emerging Global Diseases (CTEGD), University of Georgia, Athens, Georgia 30602, USA.
  • Zhao JX; State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, China. jmyue@simm.ac.cn.
  • Yue JM; Research Units of Discovery of New Drug Lead Molecules, Chinese Academy of Medical Sciences, Shanghai 201203, China.
Org Biomol Chem ; 20(45): 9000-9009, 2022 11 23.
Article em En | MEDLINE | ID: mdl-36330968
ABSTRACT
Seventeen new cephalotane-type diterpenoids, fortalides A-Q (1-17), along with five known analogues, were isolated from the seeds of Cephalotaxus fortunei var. alpina. Their structures were determined by extensive spectroscopic methods, as well as electronic circular dichroism (ECD) and X-ray crystallographic data analyses. Some isolates exhibited unusual structural features that were first found in cephalotane-type diterpenoids, such as the occurrence of the 7-oxabicyclo[4.1.1]octane moiety in 14 and 15 and the cis-arrangement of 3-OH and Me-19 in 9. Besides, the antiplasmodial activity of these compounds was evaluated in this study.
Assuntos
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cephalotaxus / Diterpenos Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cephalotaxus / Diterpenos Idioma: En Ano de publicação: 2022 Tipo de documento: Article