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High-impact opportunities to address ischemia: a focus on heart and circulatory research.
Al Rimon, Razoan; Nelson, Victoria L; Brunt, Keith R; Kassiri, Zamaneh.
Afiliação
  • Al Rimon R; Department of Physiology, Cardiovascular Research Center, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
  • Nelson VL; Department of Pharmacology, Faculty of Medicine, Dalhousie University, Saint John, New Brunswick, Canada.
  • Brunt KR; Department of Pharmacology, Faculty of Medicine, Dalhousie University, Saint John, New Brunswick, Canada.
  • Kassiri Z; Department of Physiology, Cardiovascular Research Center, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Am J Physiol Heart Circ Physiol ; 323(6): H1221-H1230, 2022 12 01.
Article em En | MEDLINE | ID: mdl-36331554
Myocardial ischemic injury and its resolution are the key determinants of morbidity or mortality in heart failure. The cause and duration of ischemia in patients vary. Numerous experimental models and methods have been developed to define genetic, metabolic, molecular, cellular, and pathophysiological mechanisms, in addition to defining structural and functional deterioration of cardiovascular performance. The rapid rise of big data, such as single-cell analysis techniques with bioinformatics, machine learning, and neural networking, brings a new level of sophistication to our understanding of myocardial ischemia. This mini-review explores the multifaceted nature of ischemic injury in the myocardium. We highlight recent state-of-the-art findings and strategies to show new directions of high-impact approach to understanding myocardial tissue remodeling. This next age of heart and circulatory physiology research will be more comprehensive and collaborative to uncover the origin, progression, and manifestation of heart failure while strengthening novel treatment strategies.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Isquemia Miocárdica / Insuficiência Cardíaca Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Isquemia Miocárdica / Insuficiência Cardíaca Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article