A multicenter study of genetic testing for Parkinson's disease in the clinical setting.
NPJ Parkinsons Dis
; 8(1): 149, 2022 Nov 04.
Article
em En
| MEDLINE
| ID: mdl-36333361
ABSTRACT
Parkinson's disease (PD) guidelines lack clear criteria for genetic evaluation. We assessed the yield and rationale of genetic testing for PD in a routine clinical setting on a multicenter cohort of 149 early-onset and familial patients by exome sequencing and semi-quantitative multiplex ligation-dependent probe amplification of evidence-based PD-associated gene panel. We show that genetic testing for PD should be considered for both early-onset and familial patients alike, and a clinical yield of about 10% in the Caucasian population can be expected.
Texto completo:
1
Base de dados:
MEDLINE
Tipo de estudo:
Clinical_trials
/
Guideline
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article