An Alternative Autophagy-Related Mechanism of Chloroquine Drug Resistance in the Malaria Parasite.
Antimicrob Agents Chemother
; 66(12): e0026922, 2022 12 20.
Article
em En
| MEDLINE
| ID: mdl-36342168
ABSTRACT
We generated highly chloroquine (CQ)-resistant (ResCQ) Plasmodium yoelii parasites by stepwise exposure to increasing concentrations of CQ and CQ-sensitive parasites (SenCQ) by parallel mock treatments. No mutations in genes that are associated with drug resistance were detected in ResCQ clones. Autophagy-related genes were highly upregulated in SenCQ compared to ResCQ parasites during CQ treatment. This indicates that CQ resistance can be developed in the malaria parasite by the inhibition of autophagy as an alternative drug resistance mechanism.
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Base de dados:
MEDLINE
Assunto principal:
Resistência a Medicamentos
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Plasmodium yoelii
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Proteínas de Protozoários
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Cloroquina
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Antimaláricos
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article