ADRA1A-Gαq signalling potentiates adipocyte thermogenesis through CKB and TNAP.
Nat Metab
; 4(11): 1459-1473, 2022 11.
Article
em En
| MEDLINE
| ID: mdl-36344764
ABSTRACT
Noradrenaline (NA) regulates cold-stimulated adipocyte thermogenesis1. Aside from cAMP signalling downstream of ß-adrenergic receptor activation, how NA promotes thermogenic output is still not fully understood. Here, we show that coordinated α1-adrenergic receptor (AR) and ß3-AR signalling induces the expression of thermogenic genes of the futile creatine cycle2,3, and that early B cell factors, oestrogen-related receptors and PGC1α are required for this response in vivo. NA triggers physical and functional coupling between the α1-AR subtype (ADRA1A) and Gαq to promote adipocyte thermogenesis in a manner that is dependent on the effector proteins of the futile creatine cycle, creatine kinase B and tissue-non-specific alkaline phosphatase. Combined Gαq and Gαs signalling selectively in adipocytes promotes a continual rise in whole-body energy expenditure, and creatine kinase B is required for this effect. Thus, the ADRA1A-Gαq-futile creatine cycle axis is a key regulator of facultative and adaptive thermogenesis.
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1
Base de dados:
MEDLINE
Assunto principal:
Creatina
/
Termogênese
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article