Rab11-FIP1C Is Dispensable for HIV-1 Replication in Primary CD4<sup>+</sup> T Cells, but Its Role Is Cell Type Dependent in Immortalized Human T-Cell Lines.

Fernandez-de Céspedes, Melissa V; Hoffman, Huxley K; Carter, Hannah; Simons, Lacy M; Naing, Lwar; Ablan, Sherimay D; Scheiblin, David A; Hultquist, Judd F; van Engelenburg, Schuyler B; Freed, Eric O

Rab11-FIP1C Is Dispensable for HIV-1 Replication in Primary CD4⁺ T Cells, but Its Role Is Cell Type Dependent in Immortalized Human T-Cell Lines.

Fernandez-de Céspedes, Melissa V; Hoffman, Huxley K; Carter, Hannah; Simons, Lacy M; Naing, Lwar; Ablan, Sherimay D; Scheiblin, David A; Hultquist, Judd F; van Engelenburg, Schuyler B; Freed, Eric O.

Afiliação

Fernandez-de Céspedes MV; HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institutegrid.48336.3a, Frederick, Maryland, USA.
Hoffman HK; Biological Sciences, University of Denver, Denver, Colorado, USA.
Carter H; HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institutegrid.48336.3a, Frederick, Maryland, USA.
Simons LM; Division of Infectious Diseases, Center for Pathogen Genomics and Microbial Evolution, Havey Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Naing L; HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institutegrid.48336.3a, Frederick, Maryland, USA.
Ablan SD; HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institutegrid.48336.3a, Frederick, Maryland, USA.
Scheiblin DA; Optical Microscopy and Analysis Laboratory, Cancer Research Technology Program, Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Hultquist JF; Division of Infectious Diseases, Center for Pathogen Genomics and Microbial Evolution, Havey Institute for Global Health, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
van Engelenburg SB; Biological Sciences, University of Denver, Denver, Colorado, USA.
Freed EO; HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institutegrid.48336.3a, Frederick, Maryland, USA.

J Virol ; 96(23): e0087622, 2022 12 14.

Article em En | MEDLINE | ID: mdl-36354340

Assuntos

Proteínas Adaptadoras de Transdução de Sinal; Linfócitos T CD4-Positivos; HIV-1; Proteínas de Membrana; Replicação Viral; Humanos; Linfócitos T CD4-Positivos/virologia; Células HeLa; Proteína gp41 do Envelope de HIV/metabolismo; HIV-1/fisiologia; Montagem de Vírus; Proteínas Adaptadoras de Transdução de Sinal/metabolismo; Proteínas de Membrana/metabolismo; Produtos do Gene env do Vírus da Imunodeficiência Humana/metabolismo

Palavras-chave

Env; FIP1C; HIV-1; Rab proteins; cytoplasmic tail; gp41; incorporation; protein trafficking; retrovirus; trafficking; transmission; virus assembly

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Replicação Viral / Linfócitos T CD4-Positivos / HIV-1 / Proteínas Adaptadoras de Transdução de Sinal / Proteínas de Membrana Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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