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Persistence of onchocerciasis in villages in Enugu and Ogun states in Nigeria following many rounds of mass distribution of ivermectin.
Ekpo, Uwem F; Eneanya, Obiora A; Nwankwo, Edith N; Soneye, Islamiat Y; Weil, Gary J; Fischer, Peter U; Nwaorgu, Obioma C.
Afiliação
  • Ekpo UF; Department of Pure and Applied Zoology, Federal University of Agriculture, Abeokuta, Ogun, Nigeria. ufekpo@hotmail.com.
  • Eneanya OA; Infectious Diseases Division, Washington University School of Medicine, St. Louis, MO, USA.
  • Nwankwo EN; Department of Parasitology and Entomology, Faculty of Biosciences, Nnamdi Azikiwe University, Awka, Anambra, Nigeria.
  • Soneye IY; Neglected Tropical Disease Control Unit, Ogun State Ministry of Health, Oke-Mosan, Abeokuta, Ogun, Nigeria.
  • Weil GJ; Infectious Diseases Division, Washington University School of Medicine, St. Louis, MO, USA.
  • Fischer PU; Infectious Diseases Division, Washington University School of Medicine, St. Louis, MO, USA.
  • Nwaorgu OC; Department of Parasitology and Entomology, Faculty of Biosciences, Nnamdi Azikiwe University, Awka, Anambra, Nigeria.
BMC Infect Dis ; 22(1): 832, 2022 Nov 10.
Article em En | MEDLINE | ID: mdl-36357828
BACKGROUND: Onchocerciasis is endemic in most local government areas (LGAs) in Enugu and Ogun states. Most meso- and hyper-endemic LGAs have received many rounds of ivermectin mass drug administration (MDA). This study aimed to determine the current prevalence of onchocerciasis in villages in Enugu and Ogun states that were formerly highly endemic and to assess progress toward elimination of the infection in areas believed to be at high risk for persistence. METHODS: Cross-sectional community surveys were conducted 8 to 12 months after the last round of MDA in 16 villages (6 in Enugu state and 10 in Ogun state) in individuals aged ≥ 18 years. Study participants were examined for the presence of palpable subcutaneous nodules. Skin snips from the posterior iliac crests were used to assess microfiladermia (Mf) prevalence and density. RESULTS: 643 subjects were palpated for nodules and 627 individuals (225 in Enugu state; 402 in Ogun state) provided skin snips. Nodule prevalence in the study villages ranged from 42 to 66.7% in Enugu state and from 0 to 25.0% in Ogun state. Mf prevalence in the Enugu and Ogun study villages ranged from 32 to 51.1% and 0 to 28.6%, respectively. Geometric mean skin Mf density in surveyed Enugu state villages ranged between 1 and 3.1 Mf/mg; these values were < 1 Mf/mg in all but one community in Ogun state villages. CONCLUSION: Results from this study show that onchocerciasis persists in adults in many villages in Enugu and Ogun states despite many prior rounds of ivermectin MDA. Prevalence was higher in villages surveyed in Enugu than in Ogun. Low Mf densities suggest the MDA program is working well to reduce disease, but more time will be required to reach the elimination goal.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oncocercose Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Humans País como assunto: Africa Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oncocercose Tipo de estudo: Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Adult / Humans País como assunto: Africa Idioma: En Ano de publicação: 2022 Tipo de documento: Article