Adipose-Derived Stem Cells (ADSCs) Supplemented with Hepatocyte Growth Factor (HGF) Attenuate Hepatic Stellate Cell Activation and Liver Fibrosis by Inhibiting the TGF-ß/Smad Signaling Pathway in Chemical-Induced Liver Fibrosis Associated with Diabetes.

Gharbia, Sami; Nazarie, Simona-Rebeca; Dinescu, Sorina; Balta, Cornel; Herman, Hildegard; Peteu, Victor Eduard; Gherghiceanu, Mihaela; Hermenean, Anca; Costache, Marieta

Gharbia, Sami; Nazarie, Simona-Rebeca; Dinescu, Sorina; Balta, Cornel; Herman, Hildegard; Peteu, Victor Eduard; Gherghiceanu, Mihaela; Hermenean, Anca; Costache, Marieta.

Afiliação

Gharbia S; Department of Biochemistry and Molecular Biology, University of Bucharest, 050663 Bucharest, Romania.
Nazarie SR; "Aurel Ardelean" Institute of Life Sciences, "Vasile Goldis" Western University of Arad, 310025 Arad, Romania.
Dinescu S; Department of Biochemistry and Molecular Biology, University of Bucharest, 050663 Bucharest, Romania.
Balta C; Department of Biochemistry and Molecular Biology, University of Bucharest, 050663 Bucharest, Romania.
Herman H; The Research Institute of the University of Bucharest (ICUB), University of Bucharest, 050663 Bucharest, Romania.
Peteu VE; "Aurel Ardelean" Institute of Life Sciences, "Vasile Goldis" Western University of Arad, 310025 Arad, Romania.
Gherghiceanu M; "Aurel Ardelean" Institute of Life Sciences, "Vasile Goldis" Western University of Arad, 310025 Arad, Romania.
Hermenean A; Victor Babes National Institute of Pathology, 050096 Bucharest, Romania.
Costache M; Victor Babes National Institute of Pathology, 050096 Bucharest, Romania.

Cells ; 11(21)2022 10 22.

Article em En | MEDLINE | ID: mdl-36359733

Assuntos

Diabetes Mellitus Experimental; Células Estreladas do Fígado; Cirrose Hepática; Animais; Camundongos; Diabetes Mellitus Experimental/complicações; Diabetes Mellitus Experimental/terapia; Diabetes Mellitus Experimental/metabolismo; Células Estreladas do Fígado/metabolismo; Fator de Crescimento de Hepatócito/metabolismo; Fator de Crescimento de Hepatócito/farmacologia; Cirrose Hepática/induzido quimicamente; Cirrose Hepática/terapia; Cirrose Hepática/metabolismo; Transdução de Sinais; Proteínas Smad/metabolismo; Células-Tronco/metabolismo; Fator de Crescimento Transformador beta/metabolismo; Fator de Crescimento Transformador beta1/metabolismo; Células-Tronco Mesenquimais

Palavras-chave

TGF-ß/Smad pathway; adipose-derived stem cells; diabetes mellitus; hepatic stellate cells; hepatocyte growth factor; liver fibrosis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Diabetes Mellitus Experimental / Células Estreladas do Fígado / Cirrose Hepática Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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