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Anthocyanins Formulated with Carboxymethyl Starch for Gastric and Intestinal Delivery.
De Sousa Sabino, Luiz Bruno; Copes, Francesco; Saulais, Solène; De Brito, Edy Sousa; Da Silva Júnior, Ivanildo José; Le, Tien Canh; Mateescu, Mircea Alexandru; Mantovani, Diego.
Afiliação
  • De Sousa Sabino LB; Department of Chemical Engineering, Federal University of Ceará, Av. Mister Hull, 2977, Campus Universitário do Pici, Fortaleza 60356-000, Ceará, Brazil.
  • Copes F; Laboratory for Biomaterials and Bioengineering, Department of Mining, Metallurgy and Materials Engineering & CHU de Québec, Regenerative Medicine Division, Laval University, Quebec City, QC G1V 0A6, Canada.
  • Saulais S; Department of Chemistry, Université du Québec à Montréal, CP 8888, Succ. Centre-Ville, Montreal, QC H3C 3P8, Canada.
  • De Brito ES; Embrapa Agroindústria Tropical, R. Dra Sara Mesquita, 2270, Fortaleza 60511-110, Ceará, Brazil.
  • Da Silva Júnior IJ; Department of Chemical Engineering, Federal University of Ceará, Av. Mister Hull, 2977, Campus Universitário do Pici, Fortaleza 60356-000, Ceará, Brazil.
  • Le TC; Department of Chemistry, Université du Québec à Montréal, CP 8888, Succ. Centre-Ville, Montreal, QC H3C 3P8, Canada.
  • Mateescu MA; Department of Chemistry, Université du Québec à Montréal, CP 8888, Succ. Centre-Ville, Montreal, QC H3C 3P8, Canada.
  • Mantovani D; Laboratory for Biomaterials and Bioengineering, Department of Mining, Metallurgy and Materials Engineering & CHU de Québec, Regenerative Medicine Division, Laval University, Quebec City, QC G1V 0A6, Canada.
Molecules ; 27(21)2022 Oct 26.
Article em En | MEDLINE | ID: mdl-36364096
ABSTRACT
Anthocyanins obtained from jambolan have been used as active agents in different carboxymethyl starch-based tablet formulations and their release profiles evaluated in simulated gastric fluids (SGF) and simulated intestinal (SIF) fluids. Structural analysis highlighted a strong interaction between anthocyanins and carboxymethyl starch, evidenced by scanning electron microscopy and infrared analysis. Tablet dissolution behavior varied according to the pH of the media, being controlled by the swelling and/or erosion of the polymeric matrix. Various formulations for immediate, fast, and sustained release of anthocyanins for 30 min, 2 h and 12 h of dissolution have been developed. It was found that monolithic carboxymethyl starch tablets loaded with powdered jambolan extract efficiently afforded the complete delivery (100% of anthocyanins) to different sites of the simulated gastrointestinal tract and ensured the stability of these pigments, which maintained their antioxidant activity.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Excipientes / Antocianinas Idioma: En Ano de publicação: 2022 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Excipientes / Antocianinas Idioma: En Ano de publicação: 2022 Tipo de documento: Article