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Ultra-thin silica shell-guarded nanoflares for high-fidelity live cell miRNA-21 imaging by fully avoiding the interference of biothiols.
Luo, Yuze; Wang, Zefeng; Li, Junqin; Yi, Wenhua; Yang, Ke; Ou, Chunlei; Deng, Le; He, Dinggeng.
Afiliação
  • Luo Y; State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Science, Hunan Normal University, Changsha 410081, P.R. China. hedinggeng@hnu.edu.cn.
  • Wang Z; State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Science, Hunan Normal University, Changsha 410081, P.R. China. hedinggeng@hnu.edu.cn.
  • Li J; State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Science, Hunan Normal University, Changsha 410081, P.R. China. hedinggeng@hnu.edu.cn.
  • Yi W; State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Science, Hunan Normal University, Changsha 410081, P.R. China. hedinggeng@hnu.edu.cn.
  • Yang K; State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Science, Hunan Normal University, Changsha 410081, P.R. China. hedinggeng@hnu.edu.cn.
  • Ou C; State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Science, Hunan Normal University, Changsha 410081, P.R. China. hedinggeng@hnu.edu.cn.
  • Deng L; State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Science, Hunan Normal University, Changsha 410081, P.R. China. hedinggeng@hnu.edu.cn.
  • He D; State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Science, Hunan Normal University, Changsha 410081, P.R. China. hedinggeng@hnu.edu.cn.
Analyst ; 147(23): 5269-5273, 2022 Nov 21.
Article em En | MEDLINE | ID: mdl-36367109
ABSTRACT
We successfully constructed a new class of nanoflares based on ultra-thin silica-coated gold nanoparticles (Au@SiO2) with the covalent binding of nucleic acids, which demonstrated more resistance to biothiols than that exhibited in the traditional Au-S binding strategy, for imaging the target miRNA-21 with high fidelity in living cells.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: MicroRNAs / Nanopartículas Metálicas Tipo de estudo: Diagnostic_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: MicroRNAs / Nanopartículas Metálicas Tipo de estudo: Diagnostic_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article