The multisensory regulation of unconventional T cell homeostasis.
Semin Immunol
; 61-64: 101657, 2022 Nov.
Article
em En
| MEDLINE
| ID: mdl-36370671
ABSTRACT
Unconventional T cells typically group γδ T cells, invariant Natural Killer T cells (NKT) and Mucosal Associated Invariant T (MAIT) cells. With their pre-activated status and biased tropism for non-lymphoid organs, they provide a rapid (innate-like) and efficient first line of defense against pathogens at strategical barrier sites, while they can also trigger chronic inflammation, and unexpectedly contribute to steady state physiology. Thus, a tight control of their homeostasis is critical to maintain tissue integrity. In this review, we discuss the recent advances of our understanding of the factors, from neuroimmune to inflammatory regulators, shaping the size and functional properties of unconventional T cell subsets in non-lymphoid organs. We present a general overview of the mechanisms common to these populations, while also acknowledging specific aspects of their diversity. We mainly focus on their maintenance at steady state and upon inflammation, highlighting some key unresolved issues and raising upcoming technical, fundamental and translational challenges.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Células T Matadoras Naturais
/
Células T Invariantes Associadas à Mucosa
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article