Triphenyl phosphate induces clastogenic effects potently in mammalian cells, human CYP1A2 and 2E1 being major activating enzymes.

Xie, Jiayi; Tu, Hongwei; Chen, Yijing; Chen, Zhihong; Yang, Zongying; Liu, Yungang

Xie, Jiayi; Tu, Hongwei; Chen, Yijing; Chen, Zhihong; Yang, Zongying; Liu, Yungang.

Afiliação

Xie J; Department of Toxicology, School of Public Health (Guangdong Provincial Key Laboratory of Tropical Disease Research), Southern Medical University, 1023 S. Shatai Road, Guangzhou, 510515, China.
Tu H; Guangdong Provincial Center for Disease Control and Prevention, Qunxian Road, Panyu District, Guangzhou, 511430, China.
Chen Y; Department of Toxicology, School of Public Health (Guangdong Provincial Key Laboratory of Tropical Disease Research), Southern Medical University, 1023 S. Shatai Road, Guangzhou, 510515, China.
Chen Z; Department of Toxicology, School of Public Health (Guangdong Provincial Key Laboratory of Tropical Disease Research), Southern Medical University, 1023 S. Shatai Road, Guangzhou, 510515, China.
Yang Z; Department of Toxicology, School of Public Health (Guangdong Provincial Key Laboratory of Tropical Disease Research), Southern Medical University, 1023 S. Shatai Road, Guangzhou, 510515, China.
Liu Y; Department of Toxicology, School of Public Health (Guangdong Provincial Key Laboratory of Tropical Disease Research), Southern Medical University, 1023 S. Shatai Road, Guangzhou, 510515, China. Electronic address: yungliu@126.com.

Chem Biol Interact ; 369: 110259, 2023 Jan 05.

Article em En | MEDLINE | ID: mdl-36372259

Assuntos

Citocromo P-450 CYP1A2; Mutagênicos; Cricetinae; Animais; Humanos; Mutagênicos/toxicidade; Citocromo P-450 CYP1A2/genética; Cricetulus; Sistema Enzimático do Citocromo P-450/metabolismo; Citocromo P-450 CYP2E1/metabolismo

Palavras-chave

Centromere protein B; Clastogenicity; Double-strand DNA breaks; Metabolic activation; Micronuclei; Triphenyl phosphate

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Citocromo P-450 CYP1A2 / Mutagênicos Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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