European survey of newborn bloodspot screening for CF: opportunity to address challenges and improve performance.
J Cyst Fibros
; 22(3): 484-495, 2023 May.
Article
em En
| MEDLINE
| ID: mdl-36372700
ABSTRACT
BACKGROUND:
The aim of this study was to record the current status of newborn bloodspot screening (NBS) for CF across Europe and assess performance.METHODS:
Survey of representatives of NBS for CF programmes across Europe. Performance was assessed through a framework developed in a previous exercise.RESULTS:
In 2022, we identified 22 national and 34 regional programmes in Europe. Barriers to establishing NBS included cost and political inertia. Performance was assessed from 2019 data reported by 21 national and 21 regional programmes. All programmes employed different protocols, with IRT-DNA the most common strategy. Six national and 11 regional programmes did not use DNA analysis.CONCLUSIONS:
Integrating DNA analysis into the NBS protocol improves PPV, but at the expense of increased carrier and CFSPID recognition. Some programmes employ strategies to mitigate these outcomes. Programmes should constantly strive to improve performance but large datasets are needed to assess outcomes reliably.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Testes Genéticos
/
Fibrose Cística
Tipo de estudo:
Diagnostic_studies
/
Screening_studies
Limite:
Humans
/
Newborn
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article