Nuclease-independent functions of RAG1 direct distinct DNA damage responses in B cells.

Johnston, Rachel; Mathias, Brendan; Crowley, Stephanie J; Schmidt, Haley A; White, Lynn S; Mosammaparast, Nima; Green, Abby M; Bednarski, Jeffrey J

Johnston, Rachel; Mathias, Brendan; Crowley, Stephanie J; Schmidt, Haley A; White, Lynn S; Mosammaparast, Nima; Green, Abby M; Bednarski, Jeffrey J.

Afiliação

Johnston R; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
Mathias B; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
Crowley SJ; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
Schmidt HA; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
White LS; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
Mosammaparast N; Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA.
Green AM; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.
Bednarski JJ; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA.

EMBO Rep ; 24(1): e55429, 2023 01 09.

Article em En | MEDLINE | ID: mdl-36382770

Assuntos

Quebras de DNA de Cadeia Dupla; Proteínas de Homeodomínio; Proteínas de Homeodomínio/genética; Proteínas de Homeodomínio/metabolismo; Linfócitos B/metabolismo; Transdução de Sinais; Células Precursoras de Linfócitos B; Dano ao DNA

Palavras-chave

B cell development; Cas9; DNA breaks; DNA damage response; RAG

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Homeodomínio / Quebras de DNA de Cadeia Dupla Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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