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SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression.
Niemeyer, Daniela; Stenzel, Saskia; Veith, Talitha; Schroeder, Simon; Friedmann, Kirstin; Weege, Friderike; Trimpert, Jakob; Heinze, Julian; Richter, Anja; Jansen, Jenny; Emanuel, Jackson; Kazmierski, Julia; Pott, Fabian; Jeworowski, Lara M; Olmer, Ruth; Jaboreck, Mark-Christian; Tenner, Beate; Papies, Jan; Walper, Felix; Schmidt, Marie L; Heinemann, Nicolas; Möncke-Buchner, Elisabeth; Baumgardt, Morris; Hoffmann, Karen; Widera, Marek; Thao, Tran Thi Nhu; Balázs, Anita; Schulze, Jessica; Mache, Christin; Jones, Terry C; Morkel, Markus; Ciesek, Sandra; Hanitsch, Leif G; Mall, Marcus A; Hocke, Andreas C; Thiel, Volker; Osterrieder, Klaus; Wolff, Thorsten; Martin, Ulrich; Corman, Victor M; Müller, Marcel A; Goffinet, Christine; Drosten, Christian.
Afiliação
  • Niemeyer D; Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Stenzel S; German Center for Infection Research, associated partner Charité, Berlin, Germany.
  • Veith T; Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Schroeder S; Berlin Institute of Health, Berlin, Germany.
  • Friedmann K; Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Weege F; German Center for Infection Research, associated partner Charité, Berlin, Germany.
  • Trimpert J; Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Heinze J; Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Richter A; Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Jansen J; Institut für Virologie, Freie Universität Berlin, Berlin, Germany.
  • Emanuel J; Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Kazmierski J; German Center for Infection Research, associated partner Charité, Berlin, Germany.
  • Pott F; Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Jeworowski LM; Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Olmer R; Berlin Institute of Health, Berlin, Germany.
  • Jaboreck MC; Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Tenner B; Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Papies J; Berlin Institute of Health, Berlin, Germany.
  • Walper F; Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Schmidt ML; Berlin Institute of Health, Berlin, Germany.
  • Heinemann N; Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Möncke-Buchner E; Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery, REBIRTH - Center for Translational Regenerative Medicine, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center f
  • Baumgardt M; Leibniz Research Laboratories for Biotechnology and Artificial Organs (LEBAO), Department of Cardiothoracic, Transplantation and Vascular Surgery, REBIRTH - Center for Translational Regenerative Medicine, Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center f
  • Hoffmann K; Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Widera M; Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Thao TTN; Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Balázs A; Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Schulze J; Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Mache C; Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Jones TC; Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Morkel M; Department of Infectious Diseases and Respiratory Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Ciesek S; Institute for Medical Virology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.
  • Hanitsch LG; Institute of Virology and Immunology, Bern, Switzerland.
  • Mall MA; Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Hocke AC; Unit 17 "Influenza and other Respiratory Viruses", Robert Koch Institute, Berlin, Germany.
  • Thiel V; Unit 17 "Influenza and other Respiratory Viruses", Robert Koch Institute, Berlin, Germany.
  • Osterrieder K; Institute of Virology, Campus Charité Mitte, Charité - Universitätsmedizin Berlin, Berlin, Germany.
  • Wolff T; Institute of Pathology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt - Universität zu Berlin, Berlin, Germany.
  • Martin U; BIH Bioportal Single Cells, Berlin Institute of Health at Charité Universitätsmedizin Berlin, Berlin, Germany.
  • Corman VM; Institute for Medical Virology, University Hospital Frankfurt, Goethe University, Frankfurt am Main, Germany.
  • Müller MA; German Center for Infection Research, DZIF, Braunschweig, Germany.
  • Goffinet C; Fraunhofer Institute for Molecular Biology and Applied Ecology (IME), Branch Translational Medicine and Pharmacology, Frankfurt am Main, Germany.
  • Drosten C; Institute of Medical Immunology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Berlin, Germany.
PLoS Biol ; 20(11): e3001871, 2022 11.
Article em En | MEDLINE | ID: mdl-36383605
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / COVID-19 Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: SARS-CoV-2 / COVID-19 Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article