Nuciferine attenuates atherosclerosis by regulating the proliferation and migration of VSMCs through the Calm4/MMP12/AKT pathway in ApoE<sup>(-/-)</sup> mice fed with High-Fat-Diet.

Xiao, Mingzhu; Xian, Cuiling; Wang, Ying; Qi, Xiaoxiao; Zhang, Rong; Liu, Zhongqiu; Cheng, Yuanyuan

Nuciferine attenuates atherosclerosis by regulating the proliferation and migration of VSMCs through the Calm4/MMP12/AKT pathway in ApoE^(-/-) mice fed with High-Fat-Diet.

Xiao, Mingzhu; Xian, Cuiling; Wang, Ying; Qi, Xiaoxiao; Zhang, Rong; Liu, Zhongqiu; Cheng, Yuanyuan.

Afiliação

Xiao M; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangdong Key Laboratory for translational Cancer research of Chinese Medicine, International Institute for Translational Chinese Medicine, School of Pharmaceutical
Xian C; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangdong Key Laboratory for translational Cancer research of Chinese Medicine, International Institute for Translational Chinese Medicine, School of Pharmaceutical
Wang Y; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangdong Key Laboratory for translational Cancer research of Chinese Medicine, International Institute for Translational Chinese Medicine, School of Pharmaceutical
Qi X; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangdong Key Laboratory for translational Cancer research of Chinese Medicine, International Institute for Translational Chinese Medicine, School of Pharmaceutical
Zhang R; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangdong Key Laboratory for translational Cancer research of Chinese Medicine, International Institute for Translational Chinese Medicine, School of Pharmaceutical
Liu Z; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangdong Key Laboratory for translational Cancer research of Chinese Medicine, International Institute for Translational Chinese Medicine, School of Pharmaceutical
Cheng Y; Joint Laboratory for Translational Cancer Research of Chinese Medicine of the Ministry of Education of the People's Republic of China, Guangdong Key Laboratory for translational Cancer research of Chinese Medicine, International Institute for Translational Chinese Medicine, School of Pharmaceutical

Phytomedicine ; 108: 154536, 2023 Jan.

Article em En | MEDLINE | ID: mdl-36395561

Assuntos

Aporfinas; Aterosclerose; Animais; Camundongos; Apolipoproteínas E; Aporfinas/farmacologia; Aterosclerose/metabolismo; Movimento Celular; Proliferação de Células; Dieta Hiperlipídica; Metaloproteinase 12 da Matriz/metabolismo; Músculo Liso Vascular; Fosfatidilinositol 3-Quinases/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo

Palavras-chave

Atherosclerosis; Calm4; MMP12; Nuciferine; PI3K-AKT pathway; Vascular smooth muscle cells

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aporfinas / Aterosclerose Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aporfinas / Aterosclerose Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article