Deconstructing the liquid architecture of human herpesvirus 8 diseases.
Br J Haematol
; 200(4): 401-403, 2023 02.
Article
em En
| MEDLINE
| ID: mdl-36397674
ABSTRACT
Human herpesvirus 8 (HHV-8), also called Kaposi sarcoma herspesvirus (KSHV), causes several human tumours, which may be associated with systemic inflammation and body cavity effusions, including a form of multicentric Castleman disease (MCD) and a novel inflammatory syndrome, KSHV inflammatory cytokine syndrome (KICS). In this issue, Zhou et al. demonstrate that HHV-8-infected lambda-restricted plasmablasts can be detected in these effusions and can be used to distinguish MCD from other HHV-8 tumours as well as to categorise KICS into distinct clinicopathological groups. These findings open a path to an integrated clinicopathological approach to HHV-8-associated inflammatory diseases and may have clinical implications. Commentary on Zhou et al. A novel approach for characterisation of KSHV-associated multicentric Castleman disease from effusions. Br J Haematol 2023;200462-475.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sarcoma de Kaposi
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Hiperplasia do Linfonodo Gigante
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Herpesvirus Humano 8
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article