Incidental FOXL2 mutated adult granulosa cell tumour of the ovary with thecoma-like foci.

Fischer, Anne Kristin; Schömig-Markiefka, Birgid; Heydt, Carina; Ratiu, Dominik; Mallmann, Peter; Meinel, Jörn; Büttner, Reinhard; Schmidt, Dietmar; Quaas, Alexander

Fischer, Anne Kristin; Schömig-Markiefka, Birgid; Heydt, Carina; Ratiu, Dominik; Mallmann, Peter; Meinel, Jörn; Büttner, Reinhard; Schmidt, Dietmar; Quaas, Alexander.

Afiliação

Fischer AK; Institute of Pathology, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany. Anne.Fischer1@uk-koeln.de.
Schömig-Markiefka B; Institute of Pathology, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Heydt C; Institute of Pathology, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Ratiu D; Department Od Gynaecology, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Mallmann P; Department Od Gynaecology, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Meinel J; Institute of Pathology, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Büttner R; Institute of Pathology, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
Schmidt D; Medical Care Center for Histology, Cytology and Molecular Diagnostics Trier, Max-Planck-Straße 5, 54296, Trier, Germany.
Quaas A; Institute of Pathology, University of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.

Virchows Arch ; 483(1): 117-124, 2023 Jul.

Article em En | MEDLINE | ID: mdl-36399188

ABSTRACT

ABSTRACT

We report on the incidental finding of a FOXL2 mutated adult granulosa cell tumour of the ovary with thecoma-like foci, a rare entity recently described by Jennifer N. Stall and Robert H. Young in a series of sixteen cases in 2019, displaying features differing from conventional adult granulosa cell tumour. Our aim is to specify the morphologic and molecular particularities of this presumably underrecognized finding, with a short presentation of the typical clinical context. Awareness of this rare and challenging neoplasm with indeterminate clinical course is crucial in routine diagnostics.

Assuntos

Tumor de Células da Granulosa; Neoplasias Ovarianas; Tumor da Célula Tecal; Adulto; Feminino; Humanos; Tumor de Células da Granulosa/diagnóstico; Tumor de Células da Granulosa/genética; Tumor de Células da Granulosa/patologia; Tumor da Célula Tecal/diagnóstico; Tumor da Célula Tecal/genética; Tumor da Célula Tecal/patologia; Neoplasias Ovarianas/genética; Neoplasias Ovarianas/patologia; Proteína Forkhead Box L2/genética; Fatores de Transcrição Forkhead/genética

Palavras-chave

Adult granulosa cell tumour; FOXL2 mutation; Functioning ovarian neoplasms; Reticulin staining; Thecoma-like foci

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Tumor da Célula Tecal / Tumor de Células da Granulosa Limite: Adult / Female / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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