Towards Alzheimer's disease-related targets: One-pot Cu(I)- mediated synthesis of new nitroindazolyltriazoles.
Bioorg Chem
; 130: 106261, 2023 01.
Article
em En
| MEDLINE
| ID: mdl-36399866
ABSTRACT
In this work, we have investigated the one pot strategy for the Cu(I)-mediated synthesis of new triazoles bearing nitroindazole moieties using different copper catalysts. The biological activity of newly synthesized nitroindazolyltriazoles towards Alzheimer's disease-related targets, namely cholinesterases, monoamine oxidases, and amyloid aggregation, were investigated. Predictions of target affinity, physicochemical parameters, gastrointestinal absorption and brain penetration were achieved by means of in silico tools.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Triazóis
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Doença de Alzheimer
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Indazóis
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article