Effects of Glucocorticoids in Murine Models of Duchenne and Limb-Girdle Muscular Dystrophy.
Methods Mol Biol
; 2587: 467-478, 2023.
Article
em En
| MEDLINE
| ID: mdl-36401044
ABSTRACT
In vivo testing of glucocorticoid steroids in dystrophic mice offers important insights in benefits and risks of those drugs in the pathological context of muscular dystrophy. Frequency of dosing changes the spectrum of glucocorticoid effects on muscle and metabolic homeostasis. Here, we describe a combination of non-invasive and invasive methods to quantitatively discriminate the specific effects of intermittent (once-weekly) versus mainstay (once-daily) regimens on muscle fibrosis, muscle function, and metabolic homeostasis in murine models of Duchenne and limb-girdle muscular dystrophies.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Distrofia Muscular de Duchenne
/
Distrofia Muscular do Cíngulo dos Membros
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article