Humans pIKK-up NLRP3 to skip NEK7.
Trends Immunol
; 43(12): 947-949, 2022 12.
Article
em En
| MEDLINE
| ID: mdl-36404209
ABSTRACT
NLRP3 inflammasome regulation is essential for controlling cell death and inflammation. Mechanistic studies in murine cells suggest a two-step model of priming and activation with an indispensable role for NEK7. However, in a recent article in Immunity, Schmacke et al. report that, in humans, transcription-independent NLRP3 activation occurs by circumventing NEK7 via IKKß.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Inflamassomos
/
Proteína 3 que Contém Domínio de Pirina da Família NLR
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article